PEC Original Annotations
|
Essentiality
|
Class
|
non-essential
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
Deletion
|
OCR10
(D)
,
OCR10,11-16 (BK5-16 / AK7-16)
(D)
|
Related gene (W3110 PEC)
|
Gene Search
|
Search MG1655 PEC by gene name:
oxyR
|
Related strains
|
Strains Search
|
Search strains by gene name:
oxyR
Search strains by all related name:
oxyR b3961 ECK3953 JW3933 momR mor
|
General information (Go to Linear View:)
|
Gene Name
|
oxyR
|
Alternative name
|
b3961,ECK3953,JW3933,momR,mor
|
Location, Length
|
4,156,513 - 4,157,430
(
+
)
;
89.59
min
;
918
(bp) ,
305
(aa)
|
Product
|
oxidative and nitrosative stress transcriptional regulator
|
Operon Name
|
oxyR
|
Note
|
activator, hydrogen peroxide-inducible genes; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_function: GO:0016564 - transcription repressor activity; GO_process: GO:0006350 - transcription
|
Function
|
regulator; Global regulatory functions
|
Gene Ontology
|
GO:0003677
;
DNA binding ( oxyR )
GO:0003700
;
transcription factor activity ( oxyR )
GO:0006350
;
transcription ( oxyR )
GO:0006355
;
regulation of transcription, DNA-dependent ( oxyR )
|
PID
|
1790399
|
EC number
(KEGG Pathway)
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
EcoGene
|
oxyR
(
EG10681
)
|
Number of removed
|
0 aa cleaved
|
SWISS-PROT
(
Show details
)
|
Entry name(Acc.no)
|
OXYR_ECOLI
(
P11721
;
P22471
)
|
- Protein name
|
Hydrogen peroxide-inducible genes activator
|
- Synonyms
|
Morphology and auto- aggregation control protein
|
- Gene name
|
OrderedLocusNames=b3961, c4922, z5519, ECs4890;
|
MMBR References
|
J Bacteriol. 1997;179:6181-6186
Transcriptional regulation of the Escherichia coli oxyR gene as a function of cell growth.
Gonzalez-Flecha, B., and B. Demple.
|
Adv Exp Med Biol. 1997;412:349-55.
A novel regulatory mechanism for a novel phase-variable outer membrane protein of Escherichia coli.
Henderson IR, Meehan M, Owen P.
(
9192040
)
|
J Bacteriol. 1995;177:1285-1291
Mutational analysis of the redox-sensitive transcriptional regulator OxyR: regions important for DNA binding and multimerization.
Kullik, I., J. Stevens, M. B. Toledano, and G. Storz.
|
J Bacteriol. 1995;177:1275-1284
Mutational analysis of the redox-sensitive transcriptional regulator OxyR: regions important for oxidation and transcriptional activation.
Kullik, I., M. B. Toledano, L. A. Tartaglia, and G. Storz.
|
Science. 1990;248(4952):189-94.
Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation.
Storz G, Tartaglia LA, Ames BN.
(
2183352
)
|
J Mol Biol. 1989;210(4):709-19.
Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stress.
Tartaglia LA, Storz G, Ames BN.
(
2693740
)
|
Science. 1998;279:1718-1721
Activation of the OxyR transcription factor by reversible disulfide bond formation.
Zheng, M., and G. Storz.
|
Sequences |
Amino acid
FASTA format
|
0001 MNIRDLEYLV ALAEHRHFRR AADSCHVSQP TLSGQIRKLE DELGVMLLER TSRKVLFTQA GMLLVDQART
0071 VLREVKVLKE MASQQGETMS GPLHIGLIPT VGPYLLPHII PMLHQTFPKL EMYLHEAQTH QLLAQLDSGK
0141 LDCVILALVK ESEAFIEVPL FDEPMLLAIY EDHPWANREC VPMADLAGEK LLMLEDGHCL RDQAMGFCFE
0211 AGADEDTHFR ATSLETLRNM VAAGSGITLL PALAVPPERK RDGVVYLPCI KPEPRRTIGL VYRPGSPLRS
0281 RYEQLAEAIR ARMDGHFDKV LKQAV
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 GTTTCTGTGA GCAATTATCA GTCAGAATGC
-070 TTGATAGGGA TAATCGTTCA TTGCTATTCT ACCTATCGCC ATGAACTATC GTGGCGATGG AGGATGGATA
0001 atgaatattc gtgatcttga gtacctggtg gcattggctg aacaccgcca ttttcggcgt gcggcagatt
0071 cctgccacgt tagccagccg acgcttagcg ggcaaattcg taagctggaa gatgagctgg gcgtgatgtt
0141 gctggagcgg accagccgta aagtgttgtt cacccaggcg ggaatgctgc tggtggatca ggcgcgtacc
0211 gtgctgcgtg aggtgaaagt ccttaaagag atggcaagcc agcagggcga gacgatgtcc ggaccgctgc
0281 acattggttt gattcccaca gttggaccgt acctgctacc gcatattatc cctatgctgc accagacctt
0351 tccaaagctg gaaatgtatc tgcatgaagc acagacccac cagttactgg cgcaactgga cagcggcaaa
0421 ctcgattgcg tgatcctcgc gctggtgaaa gagagcgaag cattcattga agtgccgttg tttgatgagc
0491 caatgttgct ggctatctat gaagatcacc cgtgggcgaa ccgcgaatgc gtaccgatgg ccgatctggc
0561 aggggaaaaa ctgctgatgc tggaagatgg tcactgtttg cgcgatcagg caatgggttt ctgttttgaa
0631 gccggggcgg atgaagatac acacttccgc gcgaccagcc tggaaactct gcgcaacatg gtggcggcag
0701 gtagcgggat cactttactg ccagcgctgg ctgtgccgcc ggagcgcaaa cgcgatgggg ttgtttatct
0771 gccgtgcatt aagccggaac cacgccgcac tattggcctg gtttatcgtc ctggctcacc gctgcgcagc
0841 cgctatgagc agctggcaga ggccatccgc gcaagaatgg atggccattt cgataaagtt ttaaaacagg
0911 cggtttaaAC CGTTTAACGC AGCTACCCGA TAGGCTTCCG CCATCGTCGG GTAGTTAAAG GTGGTGTTGA
0981 CGAAGTACTC AATAGTGTTG CCGCCACCTT TCTGTTCC
|