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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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J Mol Biol. 1990;212(2):319-29.
Design and characterization of Escherichia coli mutants devoid of Ap4N-hydrolase activity.
Leveque F, Blanchin-Roland S, Fayat G, Plateau P, Blanquet S.
(
2157025
)
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Deletion
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OCR29
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
rsmA
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Related strains
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Strains Search
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Search strains by gene name:
rsmA
Search strains by all related name:
rsmA b0051 ECK0052 JW0050 ksgA
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General information (Go to Linear View: )
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Gene Name
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rsmA
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Alternative name
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b0051,ECK0052,JW0050,ksgA
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Location, Length
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51,609 - 52,430
(
-
)
;
1.11
min
;
822
(bp) ,
273
(aa)
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Product
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16S rRNA m(6)A1518, m(6)A1519 dimethyltransferase, SAM-dependent
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Operon Name
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lptD-surA-pdxA-rsmA-apaGH
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Note
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GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009451 - RNA modification; GO_process: GO:0042493 - response to drug
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Function
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enzyme; rRNA modification; drug/analog sensitivity
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Gene Ontology
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GO:0000154
;
rRNA modification ( ksgA )
GO:0000179
;
rRNA (adenine-N6,N6-)-dimethyltransferase activity ( ksgA )
GO:0003723
;
RNA binding ( ksgA )
GO:0006364
;
rRNA processing ( ksgA )
GO:0008168
;
methyltransferase activity ( ksgA )
GO:0008649
;
rRNA methyltransferase activity ( ksgA )
GO:0016433
;
rRNA (adenine) methyltransferase activity ( ksgA )
GO:0016740
;
transferase activity ( ksgA )
GO:0046677
;
response to antibiotic ( ksgA )
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PID
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1786236
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EC number
(KEGG Pathway)
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2.1.1.-
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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KSGA_ECOLI
(
P06992
)
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- Protein name
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Dimethyladenosine transferase
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- Synonyms
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EC 2.1.1.-, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase, 16S rRNA dimethylase, High level kasugamycin resistance protein ksgA, Kasugamycin dimethyltransferase
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- Gene name
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Name=ksgA; Synonyms=rsmA; OrderedLocusNames=b0051;
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MMBR References
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Mol Gen Genet. 1980;179(1):211-6.
Genetic organization and restriction enzyme cleavage map of the ksgA-pdxA region of the Escherichia coli chromosome.
Andresson OS, Davies JE.
(
6256606
)
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Mol Gen Genet. 1980;179(1):201-9.
Isolation and characterization of lambda transducing phages for the E. coli genes ksgA and pdxA.
Andresson OS, Davies JE.
(
6450312
)
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Mol Gen Genet. 1980;179(1):217-22.
Some properties of the ribosomal RNA methyltransferase encoded by ksgA and the polarity of ksgA transcription.
Andresson OS, Davies JE.
(
7005624
)
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Nat New Biol. 1972;235(53):6-9.
Mechanism of kasugamycin resistance in Escherichia coli.
Helser TL, Davies JE, Dahlberg JE.
(
4336392
)
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Mol Gen Genet. 1986;205(3):515-22.
The gene for Escherichia coli diadenosine tetraphosphatase is located immediately clockwise to folA and forms an operon with ksgA.
Blanchin-Roland S, Blanquet S, Schmitter JM, Fayat G.
(
3031429
)
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Gene. 1985;38(1-3):65-72.
Nucleotide sequence of the ksgA gene of Escherichia coli: comparison of methyltransferases effecting dimethylation of adenosine in ribosomal RNA.
van Buul CP, van Knippenberg PH.
(
3905517
)
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| Sequences |
Amino acid
FASTA format
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0001 MNNRVHQGHL ARKRFGQNFL NDQFVIDSIV SAINPQKGQA MVEIGPGLAA LTEPVGERLD QLTVIELDRD
0071 LAARLQTHPF LGPKLTIYQQ DAMTFNFGEL AEKMGQPLRV FGNLPYNIST PLMFHLFSYT DAIADMHFML
0141 QKEVVNRLVA GPNSKAYGRL SVMAQYYCNV IPVLEVPPSA FTPPPKVDSA VVRLVPHATM PHPVKDVRVL
0211 SRITTEAFNQ RRKTIRNSLG NLFSVEVLTG MGIDPAMRAE NISVAQYCQM ANYLAENAPL QES
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 accacggcac cgcgcttgaa ctggcgggac
-070 gtggcaaagc cgatgtcggc agttttatta cggcgcttaa tctcgccatc aaaatgattg ttaacaccca
0001 atgaataatc gagtccacca gggccactta gcccgtaaac gcttcgggca aaactttctc aacgatcagt
0071 tcgtgatcga cagtattgtg tctgccatta acccgcaaaa gggccaggcg atggtcgaaa tcggccccgg
0141 tctggcggca ttgaccgaac cggtcggcga acgtctggac cagctgacgg tcatcgaact tgaccgcgat
0211 ctggcggcac gtctgcaaac gcatccattc ttaggcccga aactgacgat ttatcagcag gatgcgatga
0281 cctttaactt tggtgaactg gccgagaaaa tgggtcagcc gctgcgtgtt ttcggcaacc tgccttataa
0351 catctccacg ccgttgatgt tccatctgtt tagctatact gatgccattg ccgacatgca ctttatgttg
0421 caaaaagagg tggtgaatcg tctggttgca ggaccgaaca gcaaagcgta tggtcgatta agcgtcatgg
0491 cgcaatacta ttgcaatgtg atcccggtac tggaagtacc gccgtcagcc tttacaccac cacccaaagt
0561 ggattccgcc gtcgtgcgcc tggttcctca tgcaacgatg cctcacccgg ttaaagatgt tcgtgtgttg
0631 agccgcatca ccaccgaagc ctttaaccag cgtcgtaaaa ccattcgtaa cagcctcggc aacctgttta
0701 gcgtcgaggt gttaacggga atggggatcg acccggcgat gcgagcggaa aatatctctg tcgcgcaata
0771 ttgccagatg gcgaactatc tggcggagaa cgcgcctttg caggagagtt aacgatgatc aattcgcccc
0841 gagtgtgtat tcaggttcaa agcgtctaca ttgaggctca atcttcacct gataatgaac gttacgtttt
0911 tgcttatacc gt
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