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PEC Original Annotations
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Essentiality
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|
Class
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non-essential
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|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
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Deletion
|
OCR39
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
sbcD
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Related strains
|
|
Strains Search
|
Search strains by gene name:
sbcD
Search strains by all related name:
sbcD b0398 ECK0392 JW0388 yajA
|
General information (Go to Linear View: )
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Gene Name
|
sbcD
|
|
Alternative name
|
b0398,ECK0392,JW0388,yajA
|
|
Location, Length
|
414,974 - 416,176
(
-
)
;
8.94
min
;
1203
(bp) ,
400
(aa)
|
|
Product
|
exonuclease, dsDNA, ATP-dependent
|
|
Operon Name
|
sbcDC
|
|
Note
|
ATP-dependent dsDNA exonuclease; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006308 - DNA catabolic process
|
|
Function
|
enzyme; Degradation of DNA
|
|
Gene Ontology
|
GO:0004518
;
nuclease activity ( sbcD )
GO:0004519
;
endonuclease activity ( sbcD )
GO:0004527
;
exonuclease activity ( sbcD )
GO:0006259
;
DNA metabolic process ( sbcD )
GO:0006260
;
DNA replication ( sbcD )
GO:0006310
;
DNA recombination ( sbcD )
GO:0016787
;
hydrolase activity ( sbcD )
|
|
PID
|
1786598
|
EC number
(KEGG Pathway)
|
|
|
SWISS-PROT
(
Show details
[
1
more]
)
|
Entry name(Acc.no)
|
SBCD_ECOLI
(
P13457
)
|
|
- Protein name
|
Nuclease sbcCD subunit D.
|
|
- Synonyms
|
|
|
- Gene name
|
Name=sbcD; OrderedLocusNames=b0398, z0496, ECs0448;
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Homology Analysis
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|
BLAST
|
|
Bacteria
|
|
GTOP
|
sbcD
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of P. Furiosus Mre11 With Manganese And Damp
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Nuclease sbcCD subunit D
|
|
PSI-BLAST
|
Nuclease sbcCD subunit D
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
COG0420: DNA repair exonuclease [Escherichia coli 101-1]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
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PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
CK2_PHOSPHO_SITE
MYRISTYL
RGD
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MMBR References
|
J Bacteriol. 1992;174:1222-1228
Identification of sbcD mutations as cosuppressors of recBC that allow propagation of DNA palindromes in Escherichia coli K-12.
Gibson, F. P., D. R. F. Leach, and R. G. Lloyd.
|
Genetica. 1992;87(2):95-100.
The SbcCD protein of Escherichia coli is related to two putative nucleases in the UvrA superfamily of nucleotide-binding proteins.
Leach DR, Lloyd RG, Coulson AF.
(
1490631
)
|
Genes Cells 1996;1:285-291
The sbcC and sbcD genes of Escherichia coli encode a nuclease involved in palindrome inviability and genetic recombination.
Connelly, J. C., and D. R. Leach.
|
| Sequences |
Amino acid
FASTA format
|
0001 MRILHTSDWH LGQNFYSKSR EAEHQAFLDW LLETAQTHQV DAIIVAGDVF DTGSPPSYAR TLYNRFVVNL
0071 QQTGCHLVVL AGNHDSVATL NESRDIMAFL NTTVVASAGH APQILPRRDG TPGAVLCPIP FLRPRDIITS
0141 QAGLNGIEKQ QHLLAAITDY YQQHYADACK LRGDQPLPII ATGHLTTVGA SKSDAVRDIY IGTLDAFPAQ
0211 NFPPADYIAL GHIHRAQIIG GMEHVRYCGS PIPLSFDECG KSKYVHLVTF SNGKLESVEN LNVPVTQPMA
0281 VLKGDLASIT AQLEQWRDVS QEPPVWLDIE ITTDEYLHDI QRKIQALTES LPVEVLLVRR SREQRERVLA
0351 SQQRETLSEL SVEEVFNRRL ALEELDESQQ QRLQHLFTTT LHTLAGEHEA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 cacatatctt caggttattg atttccgtgg
-070 cgcagaaaaa agcaaatggc acatctgttt gggtataatc gcgcccatgc tttttcgcca gggaaccgtt
0001 atgcgcatcc ttcacacctc agactggcat ctcggccaga acttctacag taaaagccgc gaagctgaac
0071 atcaggcttt tcttgactgg ctgctggaga cagcacaaac ccatcaggtg gatgcgatta ttgttgccgg
0141 tgatgttttc gataccggct cgccgcccag ttacgcccgc acgttataca accgttttgt tgtcaattta
0211 cagcaaactg gctgtcatct ggtggtactg gcaggaaacc atgactcggt cgccacgctg aatgaatcgc
0281 gcgatatcat ggcgttcctc aatactaccg tggtcgccag cgccggacat gcgccgcaaa tcttgcctcg
0351 tcgcgacggg acgccaggcg cagtgctgtg ccccattccg tttttacgtc cgcgtgacat tattaccagc
0421 caggcggggc ttaacggtat tgaaaaacag cagcatttac tggcagcgat taccgattat taccaacaac
0491 actatgccga tgcctgcaaa ctgcgcggcg atcagcctct gcccatcatc gccacgggac atttaacgac
0561 cgtgggggcc agtaaaagtg acgccgtgcg tgacatttat attggcacgc tggacgcgtt tccggcacaa
0631 aactttccac cagccgacta catcgcgctc gggcatattc accgcgcaca gattattggc ggcatggaac
0701 atgttcgcta ttgcggctcc cccattccac tgagttttga tgaatgcggt aagagtaaat atgtccatct
0771 ggtgacattt tcaaacggca aattagagag cgtggaaaac ctgaacgtac cggtaacgca acccatggca
0841 gtgctgaaag gcgatctggc gtcgattacc gcacagctgg aacagtggcg cgatgtatcg caggagccac
0911 ctgtctggct ggatatcgaa atcactactg atgagtatct gcatgatatt cagcgcaaaa tccaggcatt
0981 aaccgaatca ttgcctgtcg aagtattgct ggtacgtcgg agtcgtgaac agcgcgagcg tgtgttagcc
1051 agccaacagc gtgaaaccct cagcgaactc agcgtcgaag aggtgttcaa tcgccgtctg gcactggaag
1121 aactggatga atcgcagcag caacgtctgc agcatctttt caccacgacg ttgcataccc tcgccggaga
1191 acacgaagca tgaaaattct cagcctgcgc ctgaaaaacc tgaactcatt aaaaggcgaa tggaagattg
1261 atttcacccg cgagccgttc gccagcaacg ggctgtttgc tat
|
