MG1655
W3110
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Gene Report : cca
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion OCL35 (D)  ,  OCL35-12 (D)  ,  OCL35-13 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  cca
Related strains
     Strains Search Search strains by gene name:  cca   Search strains by all related name:  cca b3056 ECK3046 JW3028

General information  (Go to Linear View:)
 Gene Name cca  
 Alternative name b3056,ECK3046,JW3028  
 Location, Length 3,199,913 - 3,201,151 (  +  ) ;   68.97 min ; 1239 (bp) ,   412 (aa) Go to Linear View
 Product fused tRNA nucleotidyl transferase/2'3'-cyclicphosphodiesterase/2'nucleotidase and phosphatase  
 Operon Name ygiM-cca  
 Note tRNA nucleotidyl transferase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009451 - RNA modification  
 Function enzyme; Aminoacyl tRNA synthetases, tRNA modification  
 Gene Ontology GO:0000049 ; tRNA binding ( cca )
GO:0000166 ; nucleotide binding ( cca )
GO:0000287 ; magnesium ion binding ( cca )
GO:0001680 ; tRNA 3'-terminal CCA addition ( cca )
GO:0003723 ; RNA binding ( cca )
GO:0003824 ; catalytic activity ( cca )
GO:0004112 ; cyclic-nucleotide phosphodiesterase activity ( cca )
GO:0004810 ; tRNA adenylyltransferase activity ( cca )
GO:0005515 ; protein binding ( cca )
GO:0005524 ; ATP binding ( cca )
GO:0006396 ; RNA processing ( cca )
GO:0008033 ; tRNA processing ( cca )
GO:0016151 ; nickel ion binding ( cca )
GO:0016437 ; tRNA cytidylyltransferase activity ( cca )
GO:0016740 ; transferase activity ( cca )
GO:0016779 ; nucleotidyltransferase activity ( cca )
GO:0016787 ; hydrolase activity ( cca )
GO:0016791 ; phosphoric monoester hydrolase activity ( cca )
GO:0042245 ; RNA repair ( cca )
GO:0046872 ; metal ion binding ( cca )
 PID 1789436  
 EC number
  (KEGG Pathway)   		2.7.7.72   3.1.4.16  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) CCA_ECOLI ( P06961 )
    -  Protein name tRNA nucleotidyltransferase  
    -  Synonyms EC 2.7.7.25, tRNA adenylyltransferase, tRNA CCA-pyrophosphorylase, CCA-adding enzyme  
    -  Gene name Name=cca; OrderedLocusNames=b3056;  

 Linear View (Whole Mode)
View Location
   3190.0  –  3215.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP cca (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystal Structure Of Human Cca-Adding Enzyme  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Multifunctional CCA protein [Includes: CCA-adding enzyme  
         PSI-BLAST Multifunctional CCA protein [Includes: CCA-adding enzyme
    nr     (database updated : 2007.02.20 )
         BLAST fused tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase and phosphatase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE GLYCOSAMINOGLYCAN    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL     

Other Cross-Reference
    COG COG0617J 
    EcoCyc cca 

MMBR References
J Biol Chem. 1986;261:6444-6449
Cloning, sequencing, and species relatedness of the Escherichia coli cca gene encoding the enzyme tRNA nucleotidyltransferase.
Cudny, H. J., J. R. Lupski, G. N. Godson, and M. P. Deutscher.

Sequences
Amino acid
FASTA format 
0001 MKIYLVGGAV RDALLGLPVK DRDWVVVGST PQEMLDAGYQ QVGRDFPVFL HPQTHEEYAL ARTERKSGSG 
0071 YTGFTCYAAP DVTLEDDLKR RDLTINALAQ DDNGEIIDPY NGLGDLQNRL LRHVSPAFGE DPLRVLRVAR 
0141 FAARYAHLGF RIADETLALM REMTHAGELE HLTPERVWKE TESALTTRNP QVFFQVLRDC GALRVLFPEI 
0211 DALFGVPAPA KWHPEIDTGI HTLMTLSMAA MLSPQVDVRF ATLCHDLGKG LTPPELWPRH HGHGPAGVKL 
0281 VEQLCQRLRV PNEIRDLARL VAEFHDLIHT FPMLNPKTIV KLFDSIDAWR KPQRVEQLAL TSEADVRGRT 
0351 GFESADYPQG RWLREAWEVA QSVPTKAVVE AGFKGVEIRE ELTRRRIAAV ASWKEQRCPK PE
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             CCCAAGCCGC AAACGCAAAG ATCGCTGGAT 
-070 GAACTAAATC GCCTTCTTCG TTGCACTGTC TTATTATTAG GAATTGTGTA TTTGACGAAG GGATGATGGC 
0001 gtgaagattt atctggtcgg tggtgctgtt cgggatgcat tgttagggct accggtcaaa gacagagatt 
0071 gggtggtggt cggcagtacg ccacaggaga tgctcgacgc gggctaccag caggtaggcc gcgattttcc 
0141 tgtgtttctg catccgcaaa cgcatgaaga gtatgcgctg gcacgtaccg aacggaaatc cggttccggt 
0211 tacaccggtt ttacttgcta tgccgcaccg gatgtcacgc tggaagatga tcttaagcgt cgcgatctga 
0281 ccattaatgc gctggcccag gacgataacg gcgagattat cgacccgtac aacggtctgg gcgatctgca 
0351 aaatcgtctg ttgcgccatg tttcccccgc ttttggcgaa gatccgttac gcgtattgcg cgtggcgcgt 
0421 tttgctgcgc gttatgccca cctcggtttt cgtattgccg atgaaactct ggcgttgatg cgcgagatga 
0491 cccatgcggg tgaactggaa cacctgacgc ctgaacgggt atggaaagag acggaaagcg ccctcaccac 
0561 ccgcaatcca caggtgttct tccaggtact gcgcgattgc ggcgcactgc gcgttttatt cccggaaatt 
0631 gacgcactgt ttggcgttcc ggcccctgcc aagtggcatc cggaaatcga tacgggtatt cataccttaa 
0701 tgacgctctc aatggcggcg atgctgagtc cgcaggtcga tgtccgtttc gcaactttat gccacgatct 
0771 cggtaaaggg ctgacgccgc cagaactctg gccgcgtcat catggtcatg gcccggcggg tgttaagtta 
0841 gtggaacaac tatgccagcg tctgcgcgtg ccaaatgaaa ttcgcgattt agccagactg gtggctgagt 
0911 ttcacgatct catccacacc ttcccaatgc tgaacccaaa aaccatcgtc aaattatttg attccatcga 
0981 tgcctggcgt aaaccgcagc gtgtcgagca actggcgctg accagcgagg ctgacgtgcg cggcagaacc 
1051 ggttttgaat cagcggacta cccgcaaggc cgctggttgc gcgaagcctg ggaagtggcg cagtcagtgc 
1121 cgacaaaagc cgtcgttgaa gcgggattta aaggtgtgga gattcgcgag gagctgaccc gacggcggat 
1191 tgcggcggta gccagctgga aggaacaacg ttgcccaaag cctgaatgaG TATTGGGCAT TTTGCCGGAT 
1261 GCGGCGTAAA CGCCTTATCC GGCTACATGT CAACGACAGT TGTAGGCCTG ATAAGACGCG CAAGCGTCGC 
1331 ATCAGGCGT