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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
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OCL54
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
hmp
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Related strains
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Strains Search
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Search strains by gene name:
hmp
Search strains by all related name:
hmp b2552 ECK2549 fsrB hmpA JW2536
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General information (Go to Linear View: )
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Gene Name
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hmp
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Alternative name
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b2552,ECK2549,fsrB,hmpA,JW2536
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Location, Length
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2,683,857 - 2,685,047
(
+
)
;
57.85
min
;
1191
(bp) ,
396
(aa)
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Product
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fused nitric oxide dioxygenase/dihydropteridine reductase 2
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Operon Name
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hmp
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Note
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dihydropteridine reductase, ferrisiderophore reductase activity
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Function
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enzyme; Energy metabolism, carbon: Electron transport
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Gene Ontology
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GO:0005344
;
oxygen transporter activity ( hmp )
GO:0005506
;
iron ion binding ( hmp )
GO:0005737
;
cytoplasm ( hmp )
GO:0006118
;
electron transport ( hmp )
GO:0006805
;
xenobiotic metabolic process ( hmp )
GO:0006810
;
transport ( hmp )
GO:0008941
;
nitric oxide dioxygenase activity ( hmp )
GO:0009636
;
response to toxin ( hmp )
GO:0015671
;
oxygen transport ( hmp )
GO:0016491
;
oxidoreductase activity ( hmp )
GO:0019825
;
oxygen binding ( hmp )
GO:0020037
;
heme binding ( hmp )
GO:0046872
;
metal ion binding ( hmp )
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PID
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1788903
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EC number
(KEGG Pathway)
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1.14.12.1
1.5.1.34
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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HMP_ECOLI
(
P24232
)
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- Protein name
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Flavohemoprotein
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- Synonyms
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Hemoglobin-like protein, Flavohemoglobin, HMP, Nitric oxide dioxygenase, EC 1.14.12.17, NO oxygenase, NOD
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- Gene name
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Name=hmp; Synonyms=hmpA, fsrB; OrderedLocusNames=b2552;
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MMBR References
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FEBS Lett. 1992;302(3):247-52.
The haemoglobin-like protein (HMP) of Escherichia coli has ferrisiderophore reductase activity and its C-terminal domain shares homology with ferredoxin NADP+ reductases.
Andrews SC, Shipley D, Keen JN, Findlay JB, Harrison PM, Guest JR.
(
1601132
)
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Mol Gen Genet. 1997;254(5):599-603.
Roles of RpoS (sigmaS), IHF and ppGpp in the expression of the hmp gene encoding the flavohemoglobin (Hmp) of Escherichia coli K-12.
Membrillo-Hernandez J, Cook GM, Poole RK.
(
9197421
)
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FEBS Lett. 1996;382(1-2):141-4.
The flavohaemoglobin (HMP) of Escherichia coli generates superoxide in vitro and causes oxidative stress in vivo.
Membrillo-Hernandez J, Ioannidis N, Poole RK.
(
8612736
)
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J Bacteriol. 1997;179:3164-3170
Paraquat regulation of hmp (flavohemoglobin) gene expression in Escherichia coli K-12 is SoxRS independent but modulated by sigmaS.
Membrillo-Hernandez, J., S. O. Kim, G. M. Cook, and R. K. Poole.
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J Bacteriol. 1996;178:5487-5492
Nitric oxide, nitrite, and Fnr regulation of hmp (flavohemoglobin) gene expression in Escherichia coli K-12.
Poole, R. K., M. F. Anjum, J. Membrillo-Hernandez, S. O. Kim, M. N. Hughes, and V. Stewart.
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Microbiology 1997;143:1557-1565
Escherichia coli flavohaemoglobin (Hmp) reduces cytochrome c and Fe(III)-hydroxamate K by electron transfer from NADH via FAD: sensitivity of oxidoreductase activity to haem-bound dioxygen.
Poole, R. K., N. J. Rogers, R. A. D'Mello, M. N. Hughes, and Y. Orii.
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J Bacteriol. 1993;175:921-925
Accumulation of the F plasmid TraJ protein in cpx mutants of Escherichia coli.
Silverman, P. M., L. Tran, R. Harris, and H. M. Gaudin.
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| Sequences |
Amino acid
FASTA format
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0001 MLDAQTIATV KATIPLLVET GPKLTAHFYD RMFTHNPELK EIFNMSNQRN GDQREALFNA IAAYASNIEN
0071 LPALLPAVEK IAQKHTSFQI KPEQYNIVGE HLLATLDEMF SPGQEVLDAW GKAYGVLANV FINREAEIYN
0141 ENASKAGGWE GTRDFRIVAK TPRSALITSF ELEPVDGGAV AEYRPGQYLG VWLKPEGFPH QEIRQYSLTR
0211 KPDGKGYRIA VKREEGGQVS NWLHNHANVG DVVKLVAPAG DFFMAVADDT PVTLISAGVG QTPMLAMLDT
0281 LAKAGHTAQV NWFHAAENGD VHAFADEVKE LGQSLPRFTA HTWYRQPSEA DRAKGQFDSE GLMDLSKLEG
0351 AFSDPTMQFY LCGPVGFMQF TAKQLVDLGV KQENIHYECF GPHKVL
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TCTTTCTGAA AAACACCAAA GAACCATTTA
-070 CATTGCAGGG CTATTTTTTA TAAGATGCAT TTGAGATACA TCAATTAAGA TGCAAAAAAA GGAAGACCAT
0001 atgcttgacg ctcaaaccat cgctacagta aaagccacca tccctttact ggtggaaacg gggccaaagt
0071 taaccgccca tttctacgac cgtatgttta ctcataaccc agaactcaaa gaaattttta acatgagtaa
0141 ccagcgtaat ggcgatcaac gtgaagccct gtttaacgct attgccgcct acgccagtaa tattgaaaac
0211 ctgcctgcgc tgctgccagc ggtagaaaaa atcgcgcaga agcacaccag cttccagatc aaaccggaac
0281 agtacaacat cgtcggtgaa cacctgttgg caacgctgga cgaaatgttc agcccggggc aggaagtgct
0351 ggacgcgtgg ggtaaagcct atggtgtact ggctaatgta tttatcaatc gcgaggcgga aatctataac
0421 gaaaacgcca gcaaagccgg tggttgggaa ggtactcgcg atttccgcat tgtggctaaa acaccgcgca
0491 gcgcgcttat caccagcttc gaactggagc cggtcgacgg tggcgcagtg gcagaatacc gtccggggca
0561 atatctcggc gtctggctga agccggaagg tttcccacat caggaaattc gtcagtactc tttgactcgc
0631 aaaccggatg gcaaaggcta tcgtattgcg gtgaaacgcg aagagggtgg gcaggtatcc aactggttgc
0701 acaatcacgc caatgttggc gatgtcgtga aactggtcgc tccggcaggt gatttcttta tggctgtcgc
0771 agatgacaca ccagtgacgt taatctctgc cggtgttggt caaacgccaa tgctggcaat gctcgacacg
0841 ctggcaaaag caggccacac agcacaagtg aactggttcc atgcggcaga aaatggcgat gttcacgcct
0911 ttgccgatga agttaaggaa ctggggcagt cactgccgcg ctttaccgcg cacacctggt atcgtcagcc
0981 gagcgaagcc gatcgcgcta aaggtcagtt tgatagcgaa ggtctgatgg atttgagcaa actggaaggt
1051 gcgttcagcg atccgacaat gcagttctat ctctgcggcc cggttggctt catgcagttt accgcgaaac
1121 agttagtgga tctgggcgtg aagcaggaaa acattcatta cgaatgcttt ggcccgcata aggtgctgta
1191 aTTTGATGTT GCCGGATGGA AACATCCGGC AACCCTTGAC GCGGTTTAAA TTGCCGCGTC GTCCTCTTCA
1261 CCGGTACGGA TGCGAATGAC CCGTGCCACG T
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