MG1655
W3110
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Gene Report : chbA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion OCL85 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  chbA
Related strains
     Strains Search Search strains by gene name:  chbA   Search strains by all related name:  chbA b1736 celC ECK1734 JW1725

General information  (Go to Linear View:)
 Gene Name chbA  
 Alternative name b1736,celC,ECK1734,JW1725  
 Location, Length 1,817,479 - 1,817,829 (  -  ) ;   39.17 min ; 351 (bp) ,   116 (aa) Go to Linear View
 Product N,N'-diacetylchitobiose-specific enzyme IIA component of PTS  
 Operon Name chbBCARFG  
 Note PTS family enzyme IIA, cellobiose/arbutin/salicin sugar-specific; GO_process: GO:0016052 - carbohydrate catabolic process  
 Function enzyme; Transport of small molecules: Carbohydrates, organic acids, alcohols  
 Gene Ontology GO:0005351 ; sugar:hydrogen ion symporter activity ( chbA )
GO:0005737 ; cytoplasm ( chbA )
GO:0006810 ; transport ( chbA )
GO:0008643 ; carbohydrate transport ( chbA )
GO:0009401 ; phosphoenolpyruvate-dependent sugar phosphotransferase system ( chbA )
GO:0016020 ; membrane ( chbA )
GO:0016740 ; transferase activity ( chbA )
 PID 1788031  
 EC number
  (KEGG Pathway)
 
2.7.1.69  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) PTCA_ECOLI ( P17335 ; Q47092; Q47093; Q47094; Q57128 )
    -  Protein name PTS system, N,N'-diacetylchitobiose-specific IIA component  
    -  Synonyms EIIA-Chb, N,N'-diacetylchitobiose-permease IIA component, Phosphotransferase enzyme II, A component, EC 2.7.1.69, EIII-Chb  
    -  Gene name OrderedLocusNames=b1736, c2135, z2766, ECs2442, SF1490, S1607;  

 Linear View (Whole Mode)
View Location
   1805.0  –  1830.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP chbA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Enzyme Iia From The Lactose Specific Pts From Lactococcus Lactis  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component (PTS system N,N'-diacetylchitobiose-specific EIIA component) (EIIA-Chb) (EIII-Chb)  
         PSI-BLAST Lactose-specific phosphotransferase enzyme IIA component
    nr     (database updated : 2007.02.20 )
         BLAST PEP-dependent phosphotransferase enzyme III [Shigella flexneri 5 str. 8401]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE CK2_PHOSPHO_SITE    MYRISTYL     

Other Cross-Reference
    EcoCyc chbA 

MMBR References
Proc Natl Acad Sci U S A. 1997;94:14367-14371
Wild-type Escherichia coli grows on the chitin disaccharide, N,N'-diacetylchitobiose, by expressing the cel operon.
Keyhani, N. O., and S. Roseman.
Mol Biol Evol. 1984;1:171-182
Directed evolution of cellobiose utilization in Escherichia coli K12.
Kricker, M., and B. G. Hall.
Genetics 1987;115:419-429
Biochemical genetics of the cryptic gene system for cellobiose utilization in Escherichia coli K12.
Kricker, M., and B. G. Hall.
Genetics 1990;124:455-471
Characterization and nucleotide sequence of the cryptic cel operon of E. coli K12.
Parker, L. L., and B. G. Hall.
J Bacteriol. 1996;178:668-674
A regulator of the flagellar regulon of Escherichia coli, flhD, also affects cell division.
Pruss, B. M., and P. Matsumura.

Sequences
Amino acid
FASTA format
0001 MMDLDNIPDT QTEAEELEEV VMGLIINSGQ ARSLAYAALK QAKQGDFAAA KAMMDQSRMA LNEAHLVQTK 
0071 LIEGDAGEGK MKVSLVLVHA QDHLMTSMLA RELITELIEL HEKLKA

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             ttgataaaga agagagcgaa gaagatatcg 
-070 ctaacgccct gaaattttaa tcgatgccgg tacgggtaat cgtgccggta agaaaagaga ggaacgatgt 
0001 atgatggatc tcgataacat tcccgatacg caaacggaag ctgaagagct ggaagaagtg gtgatggggc 
0071 tgatcatcaa ctccggacaa gcgcgcagcc tggcgtatgc ggcactgaaa caggcgaagc agggcgattt 
0141 tgccgcagca aaagccatga tggatcagtc acggatggca ttgaatgaag cgcatctggt acagacgaaa 
0211 ctgattgaag gcgatgcggg cgaaggtaag atgaaagtga gtctggtgct ggtccacgct caggatcatt 
0281 taatgacgtc catgcttgcg cgtgaactga ttactgaatt aattgagctt catgaaaaac tgaaggcata 
0351 aggagtcgat gatgcagcca gtgattaacg cgccggaaat tgccactgcc cgagaacagc agttgtttaa 
0421 tggcaaaaac ttccatgtgt ttatctataa c