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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
|
J Bacteriol. 1992;174(18):5971-7.
Cloning, sequence analysis, and overexpression of Escherichia coli folK, the gene coding for 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase.
Talarico TL, Ray PH, Dev IK, Merrill BM, Dallas WS.
(
1325970
)
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Deletion
|
OCR32
(D)
|
|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
folK
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Related strains
|
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Strains Search
|
Search strains by gene name:
folK
Search strains by all related name:
folK b0142 ECK0141 JW0138
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General information (Go to Linear View: )
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Gene Name
|
folK
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Alternative name
|
b0142,ECK0141,JW0138
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Location, Length
|
157,253 - 157,732
(
-
)
;
3.39
min
;
480
(bp) ,
159
(aa)
|
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Product
|
2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase
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Operon Name
|
pcnB-folK
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Note
|
7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; GO_process: GO:0046656 - folic acid biosynthetic process
|
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Function
|
enzyme; Biosynthesis of cofactors, carriers: Folic acid
|
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Gene Ontology
|
GO:0003848
;
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity ( folK )
GO:0009396
;
folic acid and derivative biosynthetic process ( folK )
GO:0016301
;
kinase activity ( folK )
GO:0016740
;
transferase activity ( folK )
GO:0046656
;
folic acid biosynthetic process ( folK )
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PID
|
1786335
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EC number
(KEGG Pathway)
|
2.7.6.3
|
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
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EcoGene
|
folK
(
EG11374
)
|
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Number of removed
|
1 aa cleaved
|
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SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
HPPK_ECOLI
(
P26281
)
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- Protein name
|
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
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- Synonyms
|
EC 2.7.6.3, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, PPPK
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- Gene name
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Name=folK; OrderedLocusNames=b0142;
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MMBR References
|
J Bacteriol. 1992;174:5971-5977
Cloning, sequence analysis, and overexpression of Escherichia coli folK, the gene coding for 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase.
Talarico, T. L., P. H. Ray, I. K. Dev, B. M. Merrill, and W. S. Dallas.
|
| Sequences |
Amino acid
FASTA format
|
0001 MTVAYIAIGS NLASPLEQVN AALKALGDIP ESHILTVSSF YRTPPLGPQD QPDYLNAAVA LETSLAPEEL
0071 LNHTQRIELQ QGRVRKAERW GPRTLDLDIM LFGNEVINTE RLTVPHYDMK NRGFMLWPLF EIAPELVFPD
0141 GEMLRQILHT RAFDKLNKW
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Nucleotide
FASTA format
View sequence in neighbor 100bp
|
0001 atgacagtgg cgtatattgc cataggcagc aatctggcct ctccgctgga gcaggtcaat gctgccctga
0071 aagcattagg cgatatccct gaaagccaca ttcttaccgt ttcttcgttt taccgcaccc caccgctggg
0141 gccgcaagat caacccgatt acttaaacgc agccgtggcg ctggaaacct ctcttgcacc tgaagagcta
0211 ctcaatcaca cacagcgtat tgaattgcag caaggtcgcg tccgcaaagc tgaacgctgg ggaccacgca
0281 cgctggatct cgacatcatg ctgtttggta atgaagtgat aaatactgaa cgcctgaccg ttccgcacta
0351 cgatatgaag aatcgtggat ttatgctgtg gccgctgttt gaaatcgcgc cggagttggt gtttcctgat
0421 ggggagatgt tgcgtcaaat cttacataca agagcatttg acaaattaaa caaatggtaa
|
