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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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J Bacteriol. 1992;174(23):7716-28.
FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli.
Guzman LM, Barondess JJ, Beckwith J.
(
1332942
)
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Deletion
|
OCR30,31-3 (BK2-1 / AK1-1)
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
ftsL
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Related strains
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Strains Search
|
Search strains by gene name:
ftsL
Search strains by all related name:
ftsL b0083 ECK0084 JW0081 mraR pbpB yabD
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General information (Go to Linear View: )
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Gene Name
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ftsL
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Alternative name
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b0083,ECK0084,JW0081,mraR,pbpB,yabD
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Location, Length
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91,032 - 91,397
(
+
)
;
1.96
min
;
366
(bp) ,
121
(aa)
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Product
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membrane bound cell division protein at septum containing leucine zipper motif
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Operon Name
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mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
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Note
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cell division protein; ingrowth of wall at septum
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Function
|
phenotype; Cell division
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Gene Ontology
|
GO:0005886
;
plasma membrane ( ftsL )
GO:0007049
;
cell cycle ( ftsL )
GO:0016020
;
membrane ( ftsL )
GO:0016021
;
integral to membrane ( ftsL )
GO:0051301
;
cell division ( ftsL )
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PID
|
1786271
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show simple
)
|
Entry name(Acc.no)
|
FTSL_ECOLI
(
P22187
;
Q8KMX6
)
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- Protein name
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Cell division protein ftsL.
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- Synonyms
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- Gene name
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OrderedLocusNames=b0083, c0101, z0093, ECs0087, SF0080, S0082;
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- Comments
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FUNCTION:Protein involved in cell division and cell growth. May play some role in coupling cell division and peptidoglycan physiology.
SUBCELLULAR LOCATION:Type II membrane protein. Inner membrane.
SIMILARITY:Belongs to the ftsL family.
CAUTION:Ref.3 sequence differs from that shown due to a frameshift in position 109.
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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ftsL
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
|
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Cell division protein ftsL
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PSI-BLAST
|
Cell division protein ftsL
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|
nr
(database updated :
2007.02.20
)
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BLAST
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cell division protein; ingrowth of wall at septum [Escherichia coli O157:H7 EDL933]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
LEUCINE_ZIPPER
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MMBR References
|
J Bacteriol. 1992;174:7716-7728
FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli.
Guzman, L., J. J. Barondess, and J. R. Beckwith.
|
J Bacteriol. 1989;171(10):5523-30.
New mutations fts-36, lts-33, and ftsW clustered in the mra region of the Escherichia coli chromosome induce thermosensitive cell growth and division.
Ishino F, Jung HK, Ikeda M, Doi M, Wachi M, Matsuhashi M.
(
2676977
)
|
J Bacteriol. 1989;171(11):6379-82.
Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes.
Jung HK, Ishino F, Matsuhashi M.
(
2553679
)
|
Res Microbiol. 1991;142(2-3):295-9.
Alkaline phosphatase fusions in the study of cell division genes.
Barondess JJ, Carson M, Guzman Verduzco LM, Beckwith J.
(
1656499
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MISRVTEALS KVKGSMGSHE RHALPGVIGD DLLRFGKLPL CLFICIILTA VTVVTTAHHT RLLTAQREQL
0071 VLERDALDIE WRNLILEENA LGDHSRVERI ATEKLQMQHV DPSQENIVVQ K
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 AGCTGCGAGC ACTAGGCAAG TTAATGCCGG
-070 GCGAAGAAGA GGTGGCTGAG AACCCTCGTG CCCGTAGTTC AGTTCTGCGT ATTGCAGAGA GGACGAATGC
0001 atgatcagca gagtgacaga agctctaagc aaagttaaag gatcgatggg aagccacgag cgccatgcat
0071 tgcctggtgt tatcggtgac gatcttttgc gatttgggaa gctgccactc tgcctgttca tttgcattat
0141 tttgacggcg gtgactgtgg taaccacggc gcaccatacc cgtttactga ccgctcagcg cgaacaactg
0211 gtgctggagc gagatgcttt agacattgaa tggcgcaacc tgatccttga agagaatgcg ctcggcgacc
0281 atagccgggt ggaaaggatc gccacggaaa agctgcaaat gcagcatgtt gatccgtcac aagaaaatat
0351 cgtagtgcaa aaataaGGAT AAACGCGACG CATGAAAGCA GCGGCGAAAA CGCAGAAACC AAAACGTCAG
0421 GAAGAACATG CCAACTTTAT CAGTTGGCGT TTTGCGTTGT TATGCG
|
