MG1655
W3110
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Gene Report : rseP
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
Gene. 2001;281(1-2):71-9.
Characterization of the yaeL gene product and its S2P-protease motifs in Escherichia coli.
Kanehara K, Akiyama Y, Ito K. ( 11750129 )
     Deletion OCR33,35-4 (AK4-2 / BK5-2) (D)  ,  OCR34 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  rseP
Related strains
     Strains Search Search strains by gene name:  rseP   Search strains by all related name:  rseP b0176 ecfE ECK0175 JW0171 yaeL

General information  (Go to Linear View:)
 Gene Name rseP  
 Alternative name b0176,ecfE,ECK0175,JW0171,yaeL  
 Location, Length 196,546 - 197,898 (  +  ) ;   4.24 min ; 1353 (bp) ,   450 (aa) Go to Linear View
 Product inner membrane zinc RIP metalloprotease; RpoE activator, by degrading RseA; cleaved signal peptide endoprotease  
 Operon Name rseP  
 Note  
 Function  
 Gene Ontology GO:0004222 ; metalloendopeptidase activity ( rseP )
GO:0005515 ; protein binding ( rseP )
GO:0005886 ; plasma membrane ( rseP )
GO:0006508 ; proteolysis ( rseP )
GO:0008233 ; peptidase activity ( rseP )
GO:0008237 ; metallopeptidase activity ( rseP )
GO:0008270 ; zinc ion binding ( rseP )
GO:0016020 ; membrane ( rseP )
GO:0016021 ; integral to membrane ( rseP )
GO:0016787 ; hydrolase activity ( rseP )
GO:0046872 ; metal ion binding ( rseP )
 PID 1786373  
 EC number
  (KEGG Pathway)   		3.4.24.-  
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) ECFE_ECOLI ( P37764 )
    -  Protein name Protease ecfE  
    -  Synonyms EC 3.4.24.-  
    -  Gene name Name=ecfE; OrderedLocusNames=b0176, z0187, ECs0178;  
    -  Comments
  • FUNCTION:Degrades both heat shock sigma factors rpoE and rpoH.
  • COFACTOR:Zinc (Probable).
  • SUBCELLULAR LOCATION:Integral membrane protein. Inner membrane.
  • SIMILARITY:Belongs to peptidase family M50B.
  • SIMILARITY:Contains 1 PDZ/DHR domain.  
    •   botton Entry name(Acc.no) Q8FL08 ( Q8FL08 )
        -  Protein name Protease ecfE  
        -  Synonyms EC 3.4.24.-  
        -  Gene name Name=yaeL; OrderedLocusNames=c0213;  
        -  Comments
  • SIMILARITY:Contains 1 PDZ/DHR domain.  

    •  Linear View (Whole Mode)
    View Location
       185.0  –  210.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP yaeL (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
             PSI-BLAST Chain A, Structural Insights Into The Inter-Domain Chaperoning Of Tandem Pdz Domains In Glutamate Receptor Interacting Proteins  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Protease ecfE  
             PSI-BLAST Protease ecfE
        nr     (database updated : 2007.02.20 )
             BLAST hypothetical protein Z0187 [Escherichia coli O157:H7 EDL933]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    ZINC_PROTEASE    MICROBODIES_CTER     

    Other Cross-Reference
        COG COG0750M 
        EcoCyc rseP 

    Sequences
    Amino acid
    FASTA format 
    0001 MLSFLWDLAS FIVALGVLIT VHEFGHFWVA RRCGVRVERF SIGFGKALWR RTDKLGTEYV IALIPLGGYV 
0071 KMLDERAEPV VPELRHHAFN NKSVGQRAAI IAAGPVANFI FAIFAYWLVF IIGVPGVRPV VGEIAANSIA 
0141 AEAQIAPGTE LKAVDGIETP DWDAVRLQLV DKIGDESTTI TVAPFGSDQR RDVKLDLRHW AFEPDKEDPV 
0211 SSLGIRPRGP QIEPVLENVQ PNSAASKAGL QAGDRIVKVD GQPLTQWVTF VMLVRDNPGK SLALEIERQG 
0281 SPLSLTLIPE SKPGNGKAIG FVGIEPKVIP LPDEYKVVRQ YGPFNAIVEA TDKTWQLMKL TVSMLGKLIT 
0351 GDVKLNNLSG PISIAKGAGM TAELGVVYYL PFLALISVNL GIINLFPLPV LDGGHLLFLA IEKIKGGPVS 
0421 ERVQDFCYRI GSILLVLLMG LALFNDFSRL
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp 
    -100                                             ACGGTGGTAT TTTAGATCGT ATTGATAGCC 
-070 TGACGGCTGC GGTACCGGTC TTTGCTTGCT TGTTGTTACT GGTATTCAGG ACGCTTTAAC GGAAGGTAAT 
0001 atgctgagtt ttctctggga tttggcttcg ttcatcgttg cactgggtgt acttatcacc gtgcatgaat 
0071 ttggtcattt ctgggttgcc cggcgttgtg gtgttcgcgt tgagcgtttc tcaatagggt ttggtaaggc 
0141 gctctggcgg cgaactgata agctcggcac cgaatatgtt atcgccctga tcccgttggg cggttatgtc 
0211 aaaatgctgg atgagcgcgc agaaccggtc gttccggaac tccgccacca tgccttcaat aataaatctg 
0281 tcggccaacg agcggcgatt attgccgcag gtccggttgc aaacttcatt tttgctatct ttgcctactg 
0351 gctggttttt attattggtg tgcctggcgt acgtccggtg gttggcgaaa tagcagccaa ttcgatagct 
0421 gcggaagcac aaattgcacc aggtacggaa ctaaaagccg tagatggtat cgaaacgcct gattgggatg 
0491 ccgtgcgttt gcagttggtc gataaaattg gcgatgaaag caccaccatt acagtagcgc catttggcag 
0561 cgaccaacgg cgggatgtaa agctcgattt acgtcactgg gcgtttgagc ctgataaaga agatccggta 
0631 tcttcgctgg ggattcgtcc tcgtgggccg caaattgaac ctgtactgga aaatgtgcag ccaaactcgg 
0701 cggcaagcaa ggcaggtttg caagcaggcg acaggatcgt taaagtcgat ggtcagccct taacgcagtg 
0771 ggtgaccttt gtgatgcttg tccgggataa cccgggtaaa tccttagcgt tagaaatcga aaggcagggg 
0841 agtcccttgt ctttgacatt aatcccggag agtaaaccgg gtaatggtaa agcgattggt tttgtcggta 
0911 ttgagccgaa agtcattcct ttgccagatg agtataaagt tgtacgccag tatgggccgt tcaacgccat 
0981 cgtcgaagcc acggacaaaa cgtggcagct gatgaagctg acggtcagta tgctgggaaa attgatcacc 
1051 ggtgatgtga aactgaacaa cctcagtggg ccgatctcta tcgccaaggg ggctgggatg acagcggaac 
1121 tcggggttgt ttattacctg ccgtttcttg cgcttattag cgtgaactta gggataatta acctgtttcc 
1191 gttgcccgta cttgacgggg ggcatctgct gttccttgcg atcgaaaaga tcaagggcgg accggtatcc 
1261 gagcgggttc aagacttttg ttatcgcatt ggctcgattc tgctggtgct gttaatgggg cttgcacttt 
1331 tcaatgattt ctctcggtta tgaGAGTTAG TTAGGAAGAA CGCATAATAA CGATGGCGAT GAAAAAGTTG 
1401 CTCATAGCGT CGCTGCTGTT TAGCAGCGCC ACCGTATACG GTGCTGAAGG GTT