MG1655
W3110
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Gene Report : dxr
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
Proc Natl Acad Sci U S A. 1998;95(17):9879-84.
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis.
Takahashi S, Kuzuyama T, Watanabe H, Seto H. ( 9707569 )
     Deletion OCR33,34-1 (D)  ,  OCR33,34-2 (D)  ,  OCR33,35-4 (AK4-2 / BK5-2) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  dxr
Related strains
     Strains Search Search strains by gene name:  dxr   Search strains by all related name:  dxr b0173 ECK0172 ispC JW0168 yaeM

General information  (Go to Linear View:)
 Gene Name dxr  
 Alternative name b0173,ECK0172,ispC,JW0168,yaeM  
 Location, Length 193,521 - 194,717 (  +  ) ;   4.17 min ; 1197 (bp) ,   398 (aa) Go to Linear View
 Product 1-deoxy-D-xylulose 5-phosphate reductoisomerase  
 Operon Name dxr  
 Note  
 Function putative transport; Not classified  
 Gene Ontology GO:0000287 ; magnesium ion binding ( dxr )
GO:0003824 ; catalytic activity ( dxr )
GO:0005488 ; binding ( dxr )
GO:0008152 ; metabolic process ( dxr )
GO:0008299 ; isoprenoid biosynthetic process ( dxr )
GO:0016114 ; terpenoid biosynthetic process ( dxr )
GO:0016491 ; oxidoreductase activity ( dxr )
GO:0030145 ; manganese ion binding ( dxr )
GO:0030604 ; 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity ( dxr )
GO:0046872 ; metal ion binding ( dxr )
GO:0050897 ; cobalt ion binding ( dxr )
 PID 1786369  
 EC number
  (KEGG Pathway)   		1.1.1.267  
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) DXR_ECOLI ( P45568 ; P77209 )
    -  Protein name 1-deoxy-D-xylulose 5-phosphate reductoisomerase  
    -  Synonyms EC 1.1.1.267, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase  
    -  Gene name Name=dxr; OrderedLocusNames=b0173;  
    -  Comments
  • FUNCTION:Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
  • CATALYTIC ACTIVITY:2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
  • COFACTOR:Requires a divalent cation; magnesium, manganese or cobalt.
  • ENZYME REGULATION:Inhibited by fosmidomycin.
  • PATHWAY:Nonmevalonate terpenoid biosynthesis pathway; second step.
  • SUBUNIT:Homotetramer.
  • SIMILARITY:Belongs to the DXR family.  
    •   botton Entry name(Acc.no) DXR_ECO57 ( Q8X8Y1 )
        -  Protein name 1-deoxy-D-xylulose 5-phosphate reductoisomerase  
        -  Synonyms EC 1.1.1.267, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase  
        -  Gene name Name=dxr; OrderedLocusNames=z0184, ECs0175;  
        -  Comments
  • FUNCTION:Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
  • CATALYTIC ACTIVITY:2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
  • PATHWAY:Nonmevalonate terpenoid biosynthesis pathway; second step.
  • SIMILARITY:Belongs to the DXR family.  

    •  Linear View (Whole Mode)
    View Location
       185.0  –  210.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP dxr (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
             PSI-BLAST Chain A, Crystal Structure Of Dxr In Complex With Fosmidomycin  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST 1-deoxy-D-xylulose 5-phosphate reductoisomerase  
             PSI-BLAST 1-deoxy-D-xylulose 5-phosphate reductoisomerase
        nr     (database updated : 2007.02.20 )
             BLAST Chain A, Crystal Structure Of Dxr In Complex With Fosmidomycin  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE ASN_GLYCOSYLATION    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    AMIDATION    PROKAR_LIPOPROTEIN    ATP_GTP_A     

    Other Cross-Reference
        EcoCyc dxr 

    Sequences
    Amino acid
    FASTA format 
    0001 MKQLTILGST GSIGCSTLDV VRHNPEHFRV VALVAGKNVT RMVEQCLEFS PRYAVMDDEA SAKLLKTMLQ 
0071 QQGSRTEVLS GQQAACDMAA LEDVDQVMAA IVGAAGLLPT LAAIRAGKTI LLANKESLVT CGRLFMDAVK 
0141 QSKAQLLPVD SEHNAIFQSL PQPIQHNLGY ADLEQNGVVS ILLTGSGGPF RETPLRDLAT MTPDQACRHP 
0211 NWSMGRKISV DSATMMNKGL EYIEARWLFN ASASQMEVLI HPQSVIHSMV RYQDGSVLAQ LGEPDMRTPI 
0281 AHTMAWPNRV NSGVKPLDFC KLSALTFAAP DYDRYPCLKL AMEAFEQGQA ATTALNAANE ITVAAFLAQQ 
0351 IRFTDIAALN LSVLEKMDMR EPQCVDDVLS VDANAREVAR KEVMRLAS
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp 
    -100                                             CAGTTCTGAT TTCTTGAACG ACAAAAACGC 
-070 CGCTCAGTAG ATCCTTGCGG ATCGGCTGGC GGCGTTTTGC TTTTTATTCT GTCTCAACTC TGGATGTTTC 
0001 atgaagcaac tcaccattct gggctcgacc ggctcgattg gttgcagcac gctggacgtg gtgcgccata 
0071 atcccgaaca cttccgcgta gttgcgctgg tggcaggcaa aaatgtcact cgcatggtag aacagtgcct 
0141 ggaattctct ccccgctatg ccgtaatgga cgatgaagcg agtgcgaaac ttcttaaaac gatgctacag 
0211 caacagggta gccgcaccga agtcttaagt gggcaacaag ccgcttgcga tatggcagcg cttgaggatg 
0281 ttgatcaggt gatggcagcc attgttggcg ctgctgggct gttacctacg cttgctgcga tccgcgcggg 
0351 taaaaccatt ttgctggcca ataaagaatc actggttacc tgcggacgtc tgtttatgga cgccgtaaag 
0421 cagagcaaag cgcaattgtt accggtcgat agcgaacata acgccatttt tcagagttta ccgcaaccta 
0491 tccagcataa tctgggatac gctgaccttg agcaaaatgg cgtggtgtcc attttactta ccgggtctgg 
0561 tggccctttc cgtgagacgc cattgcgcga tttggcaaca atgacgccgg atcaagcctg ccgtcatccg 
0631 aactggtcga tggggcgtaa aatttctgtc gattcggcta ccatgatgaa caaaggtctg gaatacattg 
0701 aagcgcgttg gctgtttaac gccagcgcca gccagatgga agtgctgatt cacccgcagt cagtgattca 
0771 ctcaatggtg cgctatcagg acggcagtgt tctggcgcag ctgggggaac cggatatgcg tacgccaatt 
0841 gcccacacca tggcatggcc gaatcgcgtg aactctggcg tgaagccgct cgatttttgc aaactaagtg 
0911 cgttgacatt tgccgcaccg gattatgatc gttatccatg cctgaaactg gcgatggagg cgttcgaaca 
0981 aggccaggca gcgacgacag cattgaatgc cgcaaacgaa atcaccgttg ctgcttttct tgcgcaacaa 
1051 atccgcttta cggatatcgc tgcgttgaat ttatccgtac tggaaaaaat ggatatgcgc gaaccacaat 
1121 gtgtggacga tgtgttatct gttgatgcga acgcgcgtga agtcgccaga aaagaggtga tgcgtctcgc 
1191 aagctgaGGA TAATCCGGCT ACAGAGAGTC GCGCTATTTG TTAGCGTAGG GCTTCAGTGA TATAGTCTGC 
1261 GCCATCTGAT CGTAAGTAGT TGGCTTTATA AGGTCAG