|
PEC Original Annotations
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|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCR32
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
panD
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
panD
Search strains by all related name:
panD b0131 ECK0130 JW0127
|
General information (Go to Linear View: )
|
|
Gene Name
|
panD
|
|
Alternative name
|
b0131,ECK0130,JW0127
|
|
Location, Length
|
146,314 - 146,694
(
-
)
;
3.15
min
;
381
(bp) ,
126
(aa)
|
|
Product
|
aspartate 1-decarboxylase
|
|
Operon Name
|
panD
|
|
Note
|
GO_component: GO:0005737 - cytoplasm; GO_process: GO:0015937 - coenzyme A biosynthetic process
|
|
Function
|
enzyme; Biosynthesis of cofactors, carriers: Pantothenate
|
|
Gene Ontology
|
GO:0004068
;
aspartate 1-decarboxylase activity ( panD )
GO:0005488
;
binding ( panD )
GO:0005737
;
cytoplasm ( panD )
GO:0006523
;
alanine biosynthetic process ( panD )
GO:0015940
;
pantothenate biosynthetic process ( panD )
GO:0016829
;
lyase activity ( panD )
GO:0016831
;
carboxy-lyase activity ( panD )
|
|
PID
|
1786323
|
EC number
(KEGG Pathway)
|
4.1.1.11
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
|
EcoGene
|
panD
(
EG11747
)
|
|
Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show simple
)
|
Entry name(Acc.no)
|
PAND_ECOLI
(
P31664
;
Q8KMY8
)
|
|
- Protein name
|
Aspartate 1-decarboxylase precursor
|
|
- Synonyms
|
EC 4.1.1.11, Aspartate alpha- decarboxylase
|
|
- Gene name
|
OrderedLocusNames=b0131, c0160, z0142, ECs0135, SF0128, S0130;
|
|
- Comments
|
CATALYTIC ACTIVITY:L-aspartate = beta-alanine + CO(2).
COFACTOR:Pyruvoyl group.
PATHWAY:Pantothenate biosynthesis; second branch.
SUBUNIT:Homotetramer.
SIMILARITY:Belongs to the panD family.
|
|
MMBR References
|
FEMS Microbiol Lett. 1996;143(2-3):247-52.
Characterization and sequence of the Escherichia coli panBCD gene cluster.
Merkel WK, Nichols BP.
(
8837478
)
|
J Bacteriol. 1982;149(3):916-22.
Genetic and biochemical analyses of pantothenate biosynthesis in Escherichia coli and Salmonella typhimurium.
Cronan JE Jr, Littel KJ, Jackowski S.
(
7037743
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MIRTMLQGKL HRVKVTHADL HYEGSCAIDQ DFLDAAGILE NEAIDIWNVT NGKRFSTYAI AAERGSRIIS
0071 VNGAAAHCAS VGDIVIIASF VTMPDEEART WRPNVAYFEG DNEMKRTAKA IPVQVA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 atgagtagac actaaacaaa aatcgggcaa
-070 tactgcgtga gaatttcctc aaagcaggca tcgcctgctt cgttaacgac agggtagaaa ggtagaagtt
0001 atgattcgca cgatgctgca gggcaaactc caccgcgtga aagtgactca tgcggacctg cactatgaag
0071 gttcttgcgc cattgaccag gattttcttg acgcagccgg tattctcgaa aacgaagcca ttgatatctg
0141 gaatgtcacc aacggcaagc gtttctccac ttatgccatc gcggcagaac gcggttcgag aattatttct
0211 gttaacggtg cggcggccca ctgcgccagt gtcggcgata ttgtcatcat cgccagcttc gttaccatgc
0281 cagatgaaga agctcgcacc tggcgaccca acgtcgccta ttttgaaggc gacaatgaaa tgaaacgtac
0351 cgcgaaagcg attccggtac aggttgcttg attgttatcc ctgcggctgg ttactcacca gccgcgacat
0421 cgtctccagc gaatccgttc ttaagatata aagtcgtttt agtaacaacg gattatcccc c
|
