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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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J Bacteriol. 1991;173(15):4625-36.
The murG gene of Escherichia coli codes for the UDP-N-acetylglucosamine: N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase involved in the membrane steps of peptidoglycan synthesis.
Mengin-Lecreulx D, Texier L, Rousseau M, van Heijenoort J.
(
1649817
)
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Deletion
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OCR30,31-3 (BK2-1 / AK1-1)
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
murG
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Related strains
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Strains Search
|
Search strains by gene name:
murG
Search strains by all related name:
murG b0090 ECK0091 JW0088
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General information (Go to Linear View: )
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Gene Name
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murG
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Alternative name
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b0090,ECK0091,JW0088
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Location, Length
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99,644 - 100,711
(
+
)
;
2.15
min
;
1068
(bp) ,
355
(aa)
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Product
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N-acetylglucosaminyl transferase
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Operon Name
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mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
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Note
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GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0009252 - peptidoglycan biosynthetic process
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Function
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enzyme; Murein sacculus, peptidoglycan,1.6.7 metabolism; macromolecules (cellular constituent) biosynthesis; peptidoglycan (murein),7.3 location of gene products; inner membrane
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Gene Ontology
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GO:0005886
;
plasma membrane ( murG )
GO:0005975
;
carbohydrate metabolic process ( murG )
GO:0007047
;
cell wall organization and biogenesis ( murG )
GO:0007049
;
cell cycle ( murG )
GO:0008360
;
regulation of cell shape ( murG )
GO:0009252
;
peptidoglycan biosynthetic process ( murG )
GO:0009276
;
1-2nm peptidoglycan-based cell wall ( murG )
GO:0016020
;
membrane ( murG )
GO:0016740
;
transferase activity ( murG )
GO:0016757
;
transferase activity, transferring glycosyl groups ( murG )
GO:0016758
;
transferase activity, transferring hexosyl groups ( murG )
GO:0019277
;
UDP-N-acetylgalactosamine biosynthetic process ( murG )
GO:0030246
;
carbohydrate binding ( murG )
GO:0030259
;
lipid glycosylation ( murG )
GO:0050511
;
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ( murG )
GO:0051301
;
cell division ( murG )
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PID
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1786278
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EC number
(KEGG Pathway)
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2.4.1.227
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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murG
(
EG10623
)
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Number of removed
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1 aa cleaved
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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MURG_ECOLI
(
P17443
)
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- Protein name
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UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
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- Synonyms
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EC 2.4.1.227, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
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- Gene name
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Name=murG; OrderedLocusNames=b0090;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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murG
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
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Chain A, The 1.9 Angstrom Crystal Structure Of E. Coli Murg
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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UDP-N-acetylglucosamine--N-acetylmuramyl-
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PSI-BLAST
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UDP-N-acetylglucosamine--N-acetylmuramyl-
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nr
(database updated :
2007.02.20
)
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BLAST
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Chain A, The 1.9 Angstrom Crystal Structure Of E. Coli Murg
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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ASN_GLYCOSYLATION
GLYCOSAMINOGLYCAN
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
AMIDATION
MICROBODIES_CTER
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MMBR References
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Nucleic Acids Res. 1990;18(13):4014
Nucleotide sequence involving murG and murC in the mra gene cluster region of Escherichia coli.
Ikeda M, Wachi M, Jung HK, Ishino F, Matsuhashi M.
(
2197603
)
|
J Bacteriol. 1989;171(11):6379-82.
Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes.
Jung HK, Ishino F, Matsuhashi M.
(
2553679
)
|
J Bacteriol. 1989;171(11):6126-34.
Organization of the murE-murG region of Escherichia coli: identification of the murD gene encoding the D-glutamic-acid-adding enzyme.
Mengin-Lecreulx D, Parquet C, Desviat LR, Pla J, Flouret B, Ayala JA, van Heijenoort J.
(
2681153
)
|
J Bacteriol. 1991;173(15):4625-36.
The murG gene of Escherichia coli codes for the UDP-N-acetylglucosamine: N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase involved in the membrane steps of peptidoglycan synthesis.
Mengin-Lecreulx D, Texier L, Rousseau M, van Heijenoort J.
(
1649817
)
|
J Bacteriol. 1980;144(1):438-40.
Identification of new genes in a cell envelope-cell division gene cluster of Escherichia coli: cell envelope gene murG.
Salmond GP, Lutkenhaus JF, Donachie WD.
(
6998962
)
|
| Sequences |
Amino acid
FASTA format
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0001 MSGQGKRLMV MAGGTGGHVF PGLAVAHHLM AQGWQVRWLG TADRMEADLV PKHGIEIDFI RISGLRGKGI
0071 KALIAAPLRI FNAWRQARAI MKAYKPDVVL GMGGYVSGPG GLAAWSLGIP VVLHEQNGIA GLTNKWLAKI
0141 ATKVMQAFPG AFPNAEVVGN PVRTDVLALP LPQQRLAGRE GPVRVLVVGG SQGARILNQT MPQVAAKLGD
0211 SVTIWHQSGK GSQQSVEQAY AEAGQPQHKV TEFIDDMAAA YAWADVVVCR SGALTVSEIA AAGLPALFVP
0281 FQHKDRQQYW NALPLEKAGA AKIIEQPQLS VDAVANTLAG WSRETLLTMA ERARAASIPD ATERVANEVS
0351 RVARA
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 GTTCGAGCTT ACTGATTATG TCGACAGCCA
-070 TCATGATGCT GTTGCGTATT GATTATGAAA CGCGTCTGGA GAAAGCGCAG GCGTTTGTAC GAGGTTCACG
0001 atgagtggtc aaggaaagcg attaatggtg atggcaggcg gaaccggtgg acatgtattc ccgggactgg
0071 cggttgcgca ccatctaatg gctcagggtt ggcaagttcg ctggctgggg actgccgacc gtatggaagc
0141 ggacttagtg ccaaaacatg gcatcgaaat tgatttcatt cgtatctctg gtctgcgtgg aaaaggtata
0211 aaagcactga tagctgcccc gctgcgtatc ttcaacgcct ggcgtcaggc gcgggcgatt atgaaagcgt
0281 acaaacctga cgtggtgctc ggtatgggag gctacgtgtc aggtccaggt ggtctggccg cgtggtcgtt
0351 aggcattccg gttgtacttc atgaacaaaa cggtattgcg ggcttaacca ataaatggct ggcgaagatt
0421 gccaccaaag tgatgcaggc gtttccaggt gctttcccta atgcggaagt agtgggtaac ccggtgcgta
0491 ccgatgtgtt ggcgctgccg ttgccgcagc aacgtttggc tggacgtgaa ggtccggttc gtgtgctggt
0561 agtgggtggt tctcagggcg cacgcattct taaccagaca atgccgcagg ttgctgcgaa actgggtgat
0631 tcagtcacta tctggcatca gagcggcaaa ggttcgcaac aatccgttga acaggcgtat gccgaagcgg
0701 ggcaaccgca gcataaagtg acggaattta ttgatgatat ggcggcggcg tatgcgtggg cggatgtcgt
0771 cgtttgccgc tccggtgcgt taacggtgag tgaaatcgcc gcggcaggac taccggcgtt gtttgtgccg
0841 tttcaacata aagaccgcca gcaatactgg aatgcgctac cgctggaaaa agcgggcgca gccaaaatta
0911 tcgagcagcc acagcttagc gtggatgctg tcgccaacac cctggccggg tggtcgcgag aaaccttatt
0981 aaccatggca gaacgcgccc gcgctgcatc cattccggat gccaccgagc gagtggcaaa tgaagtgagc
1051 cgggttgccc gggcgtaaTT GTAGCGATGC CTTTTGCATC GTATGAATTT AAGAAGTTAA TGGCGTAAAG
1121 AATGAATACA CAACAATTGG CAAAACTGCG TTCCATCGTG CCCGAAAT
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