|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCR30
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
ilvH
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
ilvH
Search strains by all related name:
ilvH b0078 brnP ECK0080 JW0077
|
General information (Go to Linear View: )
|
|
Gene Name
|
ilvH
|
|
Alternative name
|
b0078,brnP,ECK0080,JW0077
|
|
Location, Length
|
87,357 - 87,848
(
+
)
;
1.88
min
;
492
(bp) ,
163
(aa)
|
|
Product
|
acetolactate synthase III, thiamin-dependent, small subunit
|
|
Operon Name
|
ilvIH
|
|
Note
|
acetolactate synthase III, valine sensitive, small subunit
|
|
Function
|
enzyme; Amino acid biosynthesis: Isoleucine, Valine
|
|
Gene Ontology
|
GO:0003984
;
acetolactate synthase activity ( ilvH )
GO:0008152
;
metabolic process ( ilvH )
GO:0008652
;
amino acid biosynthetic process ( ilvH )
GO:0009082
;
branched chain family amino acid biosynthetic process ( ilvH )
GO:0016597
;
amino acid binding ( ilvH )
GO:0016740
;
transferase activity ( ilvH )
|
|
PID
|
1786266
|
EC number
(KEGG Pathway)
|
2.2.1.6
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
ILVH_ECOLI
(
P00894
;
P78046; Q47637
)
|
|
- Protein name
|
Acetolactate synthase isozyme III small subunit
|
|
- Synonyms
|
EC 2.2.1.6, AHAS- III, Acetohydroxy-acid synthase III small subunit, ALS-III
|
|
- Gene name
|
Name=ilvH; Synonyms=brnP; OrderedLocusNames=b0078;
|
|
MMBR References
|
Genet Res. 1962;3:448-460.
Valine-resistant mutants of Escherichia coli K-12.
Glover, S. W.
|
J Bacteriol. 1982;149(1):387-90.
Acetohydroxy acid synthase is a target for leucine containing peptide toxicity in Escherichia coli.
Gollop N, Tavori H, Barak Z.
(
7033214
)
|
FEMS Microbiol Lett. 1995;131(1):95-8.
Control of ilvIH transcription during amino acid downshift in stringent and relaxed strains of Escherichia coli.
Baccigalupi L, Marasco R, Ricca E, De Felice M, Sacco M.
(
7557316
)
|
Mol Gen Genet. 1991;226(1-2):332-6.
Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12 and Salmonella typhimurium LT2.
Jahreis K, Postma PW, Lengeler JW.
(
1851954
)
|
J Bacteriol. 1990;172(8):4563-70.
The ilvIH operon of Escherichia coli is positively regulated.
Platko JV, Willins DA, Calvo JM.
(
2115869
)
|
J Bacteriol. 1965;89:654-60.
REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. II. IDENTIFICATION OF TWO OPERATOR GENES.
Ramakrishnan T, Adelberg EA.
(
14273640
)
|
J Bacteriol. 1981;147(3):797-804.
Physical characterization of the ilvHI operon of Escherichia coli K-12.
Squires CH, De Felice M, Wessler SR, Calvo JM.
(
6168634
)
|
Nucleic Acids Res. 1983;11:5299-5313
Molecular structure of ilvIH and its evolutionary relationship to ilvG in Escherichia coli K-12.
Squires, C. H., M. DeFelice, J. Devereux, and J. M. Calvo.
|
J Bacteriol. 1981;148(3):998-1001.
Valine-resistant Escherichia coli K-12 strains with mutations in the ilvB operon.
Sutton A, Newman T, Francis M, Freundlich M.
(
7031038
)
|
Curr. Top. Microbiol. Immunol. 1969;1:57-76.
Regulation of the biosynthesis of the branched-chain amino acids.
Umbarger, H. E.
|
Mol Gen Genet. 1977;156(3):239-49.
Valine-sensitive acetohydroxy acid synthases in Escherichia coli K-12: unique regulation modulated by multiple genetic sites.
Davis EJ, Blatt JM, Henderson EK, Whittaker JJ, Jackson JH.
(
340906
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MRRILSVLLE NESGALSRVI GLFSQRGYNI ESLTVAPTDD PTLSRMTIQT VGDEKVLEQI EKQLHKLVDV
0071 LRVSELGQGA HVEREIMLVK IQASGYGRDE VKRNTEIFRG QIIDVTPSLY TVQLAGTSGK LDAFLASIRD
0141 VAKIVEVARS GVVGLSRGDK IMR
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TTGATGTTAC CGTCGATGGC AGCGAGCACG
-070 TCTACCCGAT GCAGATTCGC GGGGGCGGAA TGGATGAAAT GTGGTTAAGC AAAACGGAGA GAACCTGATT
0001 atgcgccgga tattatcagt cttactcgaa aatgaatcag gcgcgttatc ccgcgtgatt ggcctttttt
0071 cccagcgtgg ctacaacatt gaaagcctga ccgttgcgcc aaccgacgat ccgacattat cgcgtatgac
0141 catccagacc gtgggcgatg aaaaagtact tgagcagatc gaaaagcaat tacacaaact ggtcgatgtc
0211 ttgcgcgtga gtgagttggg gcagggcgcg catgttgagc gggaaatcat gctggtgaaa attcaggcca
0281 gcggttacgg gcgtgacgaa gtgaaacgta atacggaaat attccgtggg caaattatcg atgtcacacc
0351 ctcgctttat accgttcaat tagcaggcac cagcggtaag cttgatgcat ttttagcatc gattcgcgat
0421 gtggcgaaaa ttgtggaggt tgctcgctct ggtgtggtcg gactttcgcg cggcgataaa ataatgcgtt
0491 gaGAATGATC TCAATGCGCA ATTTACAGCC CAACATGTCA CGTTGGGCTT TTTTTGCGAA ATCAGTGGGA
0561 ACCTGGAATA AAAGCAGTTG CCGCAGTTAA TT
|
