Strain Name: off-road / Allele: rw135

Allele rw135
Strain Name off-road
Type Mutant
Genotype celsr2rw135/rw135
Affected Gene celsr2
Origin and Depositor RIKEN CBS (Hitoshi Okamoto)
Link to ZFIN ZDB-GENO-051117-3    
Information
Caudal migration of facial neurons is partly disrupted. This is because the redundant functions of celsr1a and celsr1b rescue the phenotype. Rw135 allele carries a point mutation (stop codon) in the extracellular domian of celsr2.  
The Conditions to Distribute Strains
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Wada, H., Tanaka, H., Nakayama, S., Iwasaki, M., and Okamoto, H. (2006) Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain. Development 133(23):4749-4759
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.  
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Reference

Wada H, Tanaka H, Nakayama S, Iwasaki M, Okamoto H. Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain. Development. 2006 ; 133(23) : 4749-4759 .

 
Facility RIKEN Center for Brain Science