RRC ID 68622
著者 Juarez-Carreño S, Vallejo DM, Carranza-Valencia J, Palomino-Schätzlein M, Ramon-Cañellas P, Santoro R, de Hartog E, Ferres-Marco D, Romero A, Peterson HP, Ballesta-Illan E, Pineda-Lucena A, Dominguez M, Morante J.
タイトル Body-fat sensor triggers ribosome maturation in the steroidogenic gland to initiate sexual maturation in Drosophila.
ジャーナル Cell Rep
Abstract Fat stores are critical for reproductive success and may govern maturation initiation. Here, we report that signaling and sensing fat sufficiency for sexual maturation commitment requires the lipid carrier apolipophorin in fat cells and Sema1a in the neuroendocrine prothoracic gland (PG). Larvae lacking apolpp or Sema1a fail to initiate maturation despite accruing sufficient fat stores, and they continue gaining weight until death. Mechanistically, sensing peripheral body-fat levels via the apolipophorin/Sema1a axis regulates endocytosis, endoplasmic reticulum remodeling, and ribosomal maturation for the acquisition of the PG cells' high biosynthetic and secretory capacity. Downstream of apolipophorin/Sema1a, leptin-like upd2 triggers the cessation of feeding and initiates sexual maturation. Human Leptin in the insect PG substitutes for upd2, preventing obesity and triggering maturation downstream of Sema1a. These data show how peripheral fat levels regulate the control of the maturation decision-making process via remodeling of endomembranes and ribosomal biogenesis in gland cells.
巻・号 37(2)
ページ 109830
公開日 2021-10-12
DOI 10.1016/j.celrep.2021.109830
PII S2211-1247(21)01294-8
PMID 34644570
MeSH Adipose Tissue / embryology Adipose Tissue / metabolism* Adiposity* Animals Animals, Genetically Modified Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / embryology Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Endocrine Glands / embryology Endocrine Glands / metabolism* Fatty Acid-Binding Proteins / genetics Fatty Acid-Binding Proteins / metabolism Gene Expression Regulation, Developmental Glycoproteins / genetics Glycoproteins / metabolism Larva / genetics Larva / metabolism Lipogenesis Protein Transport Ribosomes / genetics Ribosomes / metabolism* Semaphorins / genetics Semaphorins / metabolism Sexual Maturation* Signal Transduction
IF 8.109
リソース情報
ショウジョウバエ 5993R-1 5993R-2 5988R-1 5988R-3 DGRC#104917 DGRC#112830