| RRC ID |
64291
|
| 著者 |
Rai M, Coleman Z, Curley M, Nityanandam A, Platt A, Robles-Murguia M, Jiao J, Finkelstein D, Wang YD, Xu B, Fan Y, Demontis F.
|
| タイトル |
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging.
|
| ジャーナル |
Cell Metab
|
| Abstract |
Neurodegeneration in the central nervous system (CNS) is a defining feature of organismal aging that is influenced by peripheral tissues. Clinical observations indicate that skeletal muscle influences CNS aging, but the underlying muscle-to-brain signaling remains unexplored. In Drosophila, we find that moderate perturbation of the proteasome in skeletal muscle induces compensatory preservation of CNS proteostasis during aging. Such long-range stress signaling depends on muscle-secreted Amyrel amylase. Mimicking stress-induced Amyrel upregulation in muscle reduces age-related accumulation of poly-ubiquitinated proteins in the brain and retina via chaperones. Preservation of proteostasis stems from the disaccharide maltose, which is produced via Amyrel amylase activity. Correspondingly, RNAi for SLC45 maltose transporters reduces expression of Amyrel-induced chaperones and worsens brain proteostasis during aging. Moreover, maltose preserves proteostasis and neuronal activity in human brain organoids challenged by thermal stress. Thus, proteasome stress in skeletal muscle hinders retinal and brain aging by mounting an adaptive response via amylase/maltose.
|
| 巻・号 |
33(6)
|
| ページ |
1137-1154.e9
|
| 公開日 |
2021-6-1
|
| DOI |
10.1016/j.cmet.2021.03.005
|
| PII |
S1550-4131(21)00112-1
|
| PMID |
33773104
|
| PMC |
PMC8172468
|
| MeSH |
Aging / metabolism*
Amylases / physiology*
Animals
Brain / metabolism*
Brain / pathology
Cell Line
Drosophila Proteins / physiology*
Drosophila melanogaster
Humans
Neurodegenerative Diseases / metabolism*
Proteasome Endopeptidase Complex / physiology*
Retina / metabolism*
Retina / pathology
|
| IF |
21.567
|
| リソース情報 |
| ショウジョウバエ |
2155R-2
3757R-5
8221R-4
8221R-1 |
