| RRC ID |
6388
|
| 著者 |
Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP.
|
| タイトル |
Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo.
|
| ジャーナル |
Dev Cell
|
| Abstract |
Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue polarity pathway in the premorphogenesis stage of C. elegans development.
|
| 巻・号 |
17(4)
|
| ページ |
494-504
|
| 公開日 |
2009-10-1
|
| DOI |
10.1016/j.devcel.2009.08.008
|
| PII |
S1534-5807(09)00345-1
|
| PMID |
19853563
|
| PMC |
PMC2819344
|
| MeSH |
Animals
Animals, Genetically Modified
Caenorhabditis elegans / embryology*
Caenorhabditis elegans / genetics
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins
Cell Division
Cell Polarity*
Embryo, Nonmammalian / cytology
Embryo, Nonmammalian / metabolism
Embryonic Development
Gene Expression Regulation, Developmental*
Immunoenzyme Techniques
In Situ Hybridization
Oogenesis
Organogenesis
RNA, Small Interfering / pharmacology
Receptors, Peptide / physiology*
Signal Transduction*
Spindle Apparatus / physiology*
|
| IF |
10.092
|
| 引用数 |
80
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| 線虫 |
tm463
tm306 |
