論文 - 詳細
| RRC ID | 6385 |
|---|---|
| 著者 | Kim K, Sato K, Shibuya M, Zeiger DM, Butcher RA, Ragains JR, Clardy J, Touhara K, Sengupta P. |
| タイトル | Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans. |
| ジャーナル | Science |
| Abstract |
Intraspecific chemical communication is mediated by signals called pheromones. Caenorhabditis elegans secretes a mixture of small molecules (collectively termed dauer pheromone) that regulates entry into the alternate dauer larval stage and also modulates adult behavior via as yet unknown receptors. Here, we identify two heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) that mediate dauer formation in response to a subset of dauer pheromone components. The SRBC-64 and SRBC-66 GPCRs are members of the large Caenorhabditis-specific SRBC subfamily and are expressed in the ASK chemosensory neurons, which are required for pheromone-induced dauer formation. Expression of both, but not each receptor alone, confers pheromone-mediated effects on heterologous cells. Identification of dauer pheromone receptors will allow a better understanding of the signaling cascades that transduce the context-dependent effects of ecologically important chemical signals. |
| 巻・号 | 326(5955) |
| ページ | 994-8 |
| 公開日 | 2009-11-13 |
| DOI | 10.1126/science.1176331 |
| PII | 1176331 |
| PMID | 19797623 |
| PMC | PMC4448937 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology Calcium / metabolism Cell Line Chemoreceptor Cells / metabolism Cyclic AMP / metabolism Cyclic GMP / metabolism GTP-Binding Protein alpha Subunits, Gi-Go / physiology Gene Expression Regulation, Developmental Genes, Helminth Guanylate Cyclase / antagonists & inhibitors Guanylate Cyclase / metabolism Hexoses / chemistry Hexoses / physiology Humans Mutation Pheromones / physiology* Receptors, G-Protein-Coupled Reproduction Signal Transduction Transfection |
| IF | 41.846 |
| 引用数 | 120 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 線虫 | tm1946 tm2943 tm1963 |