RRC ID 6344
著者 Cohen M, Reale V, Olofsson B, Knights A, Evans P, de Bono M.
タイトル Coordinated regulation of foraging and metabolism in C. elegans by RFamide neuropeptide signaling.
ジャーナル Cell Metab
Abstract Animals modify food-seeking behavior and metabolism according to perceived food availability. Here we show that, in the roundworm C. elegans, release of neuropeptides from interneurons that are directly postsynaptic to olfactory, gustatory, and thermosensory neurons coordinately regulates behavior and metabolism. Animals lacking these neuropeptides, encoded by the flp-18 gene, are defective in chemosensation and foraging, accumulate excess fat, and exhibit reduced oxygen consumption. Two G protein-coupled receptors of the NPY/RFamide family, NPR-4 and NPR-5, are activated by FLP-18 peptides in vitro and exhibit mutant phenotypes that recapitulate those of flp-18 mutants. Our data suggest that sensory input can coordinately regulate behavior and metabolism via NPY/RFamide-like receptors. They suggest that peptidergic feedback from interneurons regulates sensory neuron activity, and that at least some of this communication occurs extrasynaptically. Extrasynaptic neuropeptide signaling may greatly increase the computational capacity of neural circuits.
巻・号 9(4)
ページ 375-85
公開日 2009-4-1
DOI 10.1016/j.cmet.2009.02.003
PII S1550-4131(09)00041-2
PMID 19356718
MeSH Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Feeding Behavior* Interneurons / cytology Interneurons / metabolism Intestinal Mucosa / metabolism Intestines / cytology Lipid Metabolism Models, Biological Mutation / genetics Neuropeptide Y / metabolism Neuropeptides / metabolism* Odorants Organ Specificity Peptides / metabolism Phenotype Receptors, Cell Surface / metabolism Signal Transduction* Xenopus
IF 21.567
引用数 56
WOS 分野 ENDOCRINOLOGY & METABOLISM CELL BIOLOGY
リソース情報
線虫 tm1583 tm1782 tm1497 tm1553 tm1498 tm1504