RRC ID 59482
著者 Dowen RH.
タイトル CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans.
ジャーナル Dev Cell
Abstract The molecular basis of how animals integrate metabolic, developmental, and environmental information before committing resources to reproduction is an unresolved issue in developmental biology. In C. elegans, adult animals reallocate fat stores from intestinal cells to the germline via low-density lipoprotein (LDL)-like particles to promote embryogenesis. Here, I demonstrate that two conserved homeodomain transcription factors, CEH-60/PBX and UNC-62/MEIS, coordinate a transcriptional network that supports reproduction while suppressing longevity and stress-response pathways. The CEH-60:UNC-62 heterodimer serves an unanticipated dual function in intestinal nuclei by directly activating the expression of lipoprotein genes while directly repressing stress-responsive genes. Consequently, ceh-60 mutants display fat storage defects, a dramatic lifespan extension, and hyper-activation of innate immunity genes. Finally, CEH-60 associates with PQM-1 at the DAF-16-associated element within the promoters of stress-responsive genes to control gene expression. Thus, CEH-60 governs an elaborate transcriptional network that balances stress responses and longevity against reproduction during developmental transitions.
巻・号 49(2)
ページ 235-250.e7
公開日 2019-4-22
DOI 10.1016/j.devcel.2019.03.002
PII S1534-5807(19)30179-0
PMID 30956009
MeSH Animals Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology Embryonic Development Gene Expression Regulation, Developmental / genetics Homeodomain Proteins / metabolism* Homeodomain Proteins / physiology Longevity / physiology Pre-B-Cell Leukemia Transcription Factor 1 / metabolism* Pre-B-Cell Leukemia Transcription Factor 1 / physiology Promoter Regions, Genetic / genetics Reproduction / physiology* Trans-Activators / metabolism Transcription Factors / metabolism* Transcription Factors / physiology Vitellogenesis / physiology
IF 9.19
引用数 6
リソース情報
線虫 tm4063