RRC ID 59471
著者 Chute CD, DiLoreto EM, Zhang YK, Reilly DK, Rayes D, Coyle VL, Choi HJ, Alkema MJ, Schroeder FC, Srinivasan J.
タイトル Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans.
ジャーナル Nat Commun
Abstract Biogenic amine neurotransmitters play a central role in metazoan biology, and both their chemical structures and cognate receptors are evolutionarily conserved. Their primary roles are in cell-to-cell signaling, as biogenic amines are not normally recruited for communication between separate individuals. Here, we show that in the nematode C. elegans, a neurotransmitter-sensing G protein-coupled receptor, TYRA-2, is required for avoidance responses to osas#9, an ascaroside pheromone that incorporates the neurotransmitter, octopamine. Neuronal ablation, cell-specific genetic rescue, and calcium imaging show that tyra-2 expression in the nociceptive neuron, ASH, is necessary and sufficient to induce osas#9 avoidance. Ectopic expression in the AWA neuron, which is generally associated with attractive responses, reverses the response to osas#9, resulting in attraction instead of avoidance behavior, confirming that TYRA-2 partakes in the sensing of osas#9. The TYRA-2/osas#9 signaling system represents an inter-organismal communication channel that evolved via co-option of a neurotransmitter and its cognate receptor.
巻・号 10(1)
ページ 3186
公開日 2019-7-18
DOI 10.1038/s41467-019-11240-7
PII 10.1038/s41467-019-11240-7
PMID 31320626
PMC PMC6639374
MeSH Animals Avoidance Learning / physiology* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Communication / physiology* Nociceptors / metabolism Octopamine / metabolism* Receptors, Biogenic Amine / genetics Receptors, Biogenic Amine / metabolism* Signal Transduction
IF 11.878
引用数 2
リソース情報
線虫 tm1846