| RRC ID |
59456
|
| 著者 |
Buis A, Bellemin S, Goudeau J, Monnier L, Loiseau N, Guillou H, Aguilaniu H.
|
| タイトル |
Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans.
|
| ジャーナル |
Cell Rep
|
| Abstract |
Dietary restriction is known to extend the lifespan and reduce fat stores in most species tested to date, but the molecular mechanisms linking these events remain unclear. Here, we found that bacterial deprivation of Caenorhabditis elegans leads to lifespan extension with concomitant mobilization of fat stores. We find that LIPL-5 expression is induced by starvation and that the LIPL-5 lipase is present in coelomocyte cells and regulates fat catabolism and longevity during the bacterial deprivation response. Either LIPL-5 or coelomocyte deficiency prevents the rapid mobilization of intestinal triacylglycerol and enhanced lifespan extension in response to bacterial deprivation, whereas the combination of both defects has no additional or synergistic effect. Thus, the capacity to mobilize fat via LIPL-5 is directly linked to an animal's capacity to withstand long-term nutrient deprivation. Our data establish a role for LIPL-5 and coelomocytes in regulating fat consumption and lifespan extension upon DR.
|
| 巻・号 |
28(4)
|
| ページ |
1041-1049.e4
|
| 公開日 |
2019-7-23
|
| DOI |
10.1016/j.celrep.2019.06.064
|
| PII |
S2211-1247(19)30837-X
|
| PMID |
31340142
|
| PMC |
PMC6667774
|
| MeSH |
Animals
Bacteria / metabolism
Caenorhabditis elegans / cytology*
Caenorhabditis elegans / enzymology*
Caenorhabditis elegans / microbiology
Caenorhabditis elegans Proteins / metabolism*
Lipase / metabolism*
Lipid Metabolism*
Longevity / physiology*
Lysosomes / metabolism
Mutation / genetics
Starvation / metabolism*
|
| IF |
7.815
|
| 引用数 |
2
|
| リソース情報 |
| 線虫 |
tm4417 |
