| RRC ID |
59387
|
| 著者 |
Moll L, Roitenberg N, Bejerano-Sagie M, Boocholez H, Carvalhal Marques F, Volovik Y, Elami T, Siddiqui AA, Grushko D, Biram A, Lampert B, Achache H, Ravid T, Tzur YB, Cohen E.
|
| タイトル |
The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans.
|
| ジャーナル |
Elife
|
| Abstract |
Although aging-regulating pathways were discovered a few decades ago, it is not entirely clear how their activities are orchestrated, to govern lifespan and proteostasis at the organismal level. Here, we utilized the nematode Caenorhabditis elegans to examine whether the alteration of aging, by reducing the activity of the Insulin/IGF signaling (IIS) cascade, affects protein SUMOylation. We found that IIS activity promotes the SUMOylation of the germline protein, CAR-1, thereby shortening lifespan and impairing proteostasis. In contrast, the expression of mutated CAR-1, that cannot be SUMOylated at residue 185, extends lifespan and enhances proteostasis. A mechanistic analysis indicated that CAR-1 mediates its aging-altering functions, at least partially, through the notch-like receptor glp-1. Our findings unveil a novel regulatory axis in which SUMOylation is utilized to integrate the aging-controlling functions of the IIS and of the germline and provide new insights into the roles of SUMOylation in the regulation of organismal aging.
|
| 巻・号 |
7
|
| 公開日 |
2018-11-7
|
| DOI |
10.7554/eLife.38635
|
| PII |
38635
|
| PMID |
30403374
|
| PMC |
PMC6277199
|
| MeSH |
Aging / metabolism*
Animals
Caenorhabditis elegans / genetics
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / metabolism
Gene Knockdown Techniques
Germ Cells / metabolism
Gonads / metabolism
Insulin / metabolism*
Insulin-Like Growth Factor I / metabolism*
Longevity
Models, Biological
Proteostasis*
Signal Transduction*
Stress, Physiological
Sumoylation*
Transcription, Genetic
|
| IF |
7.551
|
| 引用数 |
2
|
| リソース情報 |
| 線虫 |
tm1753 |
