論文 - 詳細
RRC ID | 59346 |
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著者 | Gao K, Li Y, Hu S, Liu Y. |
タイトル | SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. |
ジャーナル | Elife |
Abstract |
Animals respond to mitochondrial stress with the induction of mitochondrial unfolded protein response (UPRmt). A cascade of events occur upon UPRmt activation, ultimately triggering a transcriptional response governed by two transcription factors: DVE-1 and ATFS-1. Here we identify SUMO-specific peptidase ULP-4 as a positive regulator of C. elegans UPRmt to control SUMOylation status of DVE-1 and ATFS-1. SUMOylation affects these two axes in the transcriptional program of UPRmt with distinct mechanisms: change of DVE-1 subcellular localization vs. change of ATFS-1 stability and activity. Our findings reveal a post-translational modification that promotes immune response and lifespan extension during mitochondrial stress. |
巻・号 | 8 |
公開日 | 2019-1-15 |
DOI | 10.7554/eLife.41792 |
PII | 41792 |
PMID | 30642431 |
PMC | PMC6355198 |
MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cysteine Endopeptidases / genetics Cysteine Endopeptidases / metabolism* Immunity, Innate* Longevity / physiology* Lysine / metabolism Mitochondria / metabolism* Models, Biological Protein Stability Signal Transduction Sumoylation Transcription, Genetic Unfolded Protein Response* |
IF | 7.551 |
引用数 | 4 |
リソース情報 | |
線虫 | tm1597 tm4525 |