RRC ID 59346
著者 Gao K, Li Y, Hu S, Liu Y.
タイトル SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.
ジャーナル Elife
Abstract Animals respond to mitochondrial stress with the induction of mitochondrial unfolded protein response (UPRmt). A cascade of events occur upon UPRmt activation, ultimately triggering a transcriptional response governed by two transcription factors: DVE-1 and ATFS-1. Here we identify SUMO-specific peptidase ULP-4 as a positive regulator of C. elegans UPRmt to control SUMOylation status of DVE-1 and ATFS-1. SUMOylation affects these two axes in the transcriptional program of UPRmt with distinct mechanisms: change of DVE-1 subcellular localization vs. change of ATFS-1 stability and activity. Our findings reveal a post-translational modification that promotes immune response and lifespan extension during mitochondrial stress.
巻・号 8
公開日 2019-1-15
DOI 10.7554/eLife.41792
PII 41792
PMID 30642431
PMC PMC6355198
MeSH Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cysteine Endopeptidases / genetics Cysteine Endopeptidases / metabolism* Immunity, Innate* Longevity / physiology* Lysine / metabolism Mitochondria / metabolism* Models, Biological Protein Stability Signal Transduction Sumoylation Transcription, Genetic Unfolded Protein Response*
IF 7.551
引用数 4
リソース情報
線虫 tm1597 tm4525