論文 - 詳細
| RRC ID | 59333 |
|---|---|
| 著者 | Day NJ, Ellenbecker M, Voronina E. |
| タイトル | Caenorhabditis elegans DLC-1 associates with ribonucleoprotein complexes to promote mRNA regulation. |
| ジャーナル | FEBS Lett |
| Abstract |
Ribonucleoprotein complexes, which contain mRNAs and their regulator proteins, carry out post-transcriptional control of gene expression. The function of many RNA-binding proteins depends on their association with cofactors. Here, we use a genomic approach to identify transcripts associated with DLC-1, a protein previously identified as a cofactor of two unrelated RNA-binding proteins that act in the Caenorhabditis elegans germline. Among the 2732 potential DLC-1 targets, most are germline mRNAs associated with oogenesis. Removal of DLC-1 affects expression of its targets expressed in the oocytes, meg-1 and meg-3. We propose that DLC-1 acts as a cofactor for multiple ribonucleoprotein complexes, including the ones regulating gene expression during oogenesis. |
| 巻・号 | 592(22) |
| ページ | 3683-3695 |
| 公開日 | 2018-11-1 |
| DOI | 10.1002/1873-3468.13259 |
| PMID | 30264890 |
| PMC | PMC6263831 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Carrier Proteins / genetics Carrier Proteins / metabolism Dyneins / genetics* Dyneins / metabolism Female Gene Expression Profiling* Oocytes / metabolism Oogenesis / genetics Protein Binding RNA Interference RNA, Messenger / genetics* RNA, Messenger / metabolism Ribonucleoproteins / genetics* Ribonucleoproteins / metabolism |
| IF | 2.675 |
| 引用数 | 2 |
| リソース情報 | |
| 線虫 | tm3153 tm611 |