| RRC ID |
59323
|
| 著者 |
Burton NO, Dwivedi VK, Burkhart KB, Kaplan REW, Baugh LR, Horvitz HR.
|
| タイトル |
Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C. elegans mediates its response to both osmotic stress and starvation. We report that in response to osmotic stress the cytosolic sulfotransferase SSU-1 antagonizes insulin-like signaling and promotes developmental arrest. Both SSU-1 and the DAF-16 FOXO transcription factor, which is activated when insulin signaling is low, are needed to drive specific responses to reduced insulin-like signaling. We demonstrate that SSU-1 functions in a single pair of sensory neurons to control intercellular signaling via the nuclear hormone receptor NHR-1 and promote both the specific transcriptional response to osmotic stress and altered lysophosphatidylcholine metabolism. Our results show the requirement of a sulfotransferase-nuclear hormone receptor neurohormonal signaling pathway for some but not all consequences of reduced insulin-like signaling.
|
| 巻・号 |
9(1)
|
| ページ |
5152
|
| 公開日 |
2018-12-4
|
| DOI |
10.1038/s41467-018-07640-w
|
| PII |
10.1038/s41467-018-07640-w
|
| PMID |
30514845
|
| PMC |
PMC6279808
|
| MeSH |
Animals
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / antagonists & inhibitors
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism
Cloning, Molecular
Embryo, Nonmammalian
Embryonic Development / genetics
Forkhead Transcription Factors / antagonists & inhibitors
Forkhead Transcription Factors / metabolism
Gene Expression Regulation, Developmental
Insulin / metabolism
Lysophosphatidylcholines / metabolism
Mutagenesis
Nerve Tissue Proteins / drug effects*
Neurotransmitter Agents / metabolism*
Osmotic Pressure
RNA, Messenger / biosynthesis
RNA, Messenger / genetics
Receptor, Insulin / drug effects*
Receptor, Insulin / metabolism
Receptors, Cytoplasmic and Nuclear / metabolism
Sensory Receptor Cells / drug effects
Signal Transduction / drug effects*
Signal Transduction / physiology*
Starvation
Stress, Physiological
Sulfotransferases / antagonists & inhibitors*
Sulfotransferases / genetics
Sulfotransferases / metabolism
|
| IF |
11.878
|
| 引用数 |
4
|
| リソース情報 |
| 線虫 |
tm1117 |
