| RRC ID |
58158
|
| 著者 |
Wu C, Li Z, Ding X, Guo X, Sun Y, Wang X, Hu Y, Li T, La X, Li J, Li JA, Li W, Xue L.
|
| タイトル |
Snail modulates JNK-mediated cell death in Drosophila.
|
| ジャーナル |
Cell Death Dis
|
| Abstract |
Cell death plays a pivotal role in animal development and tissue homeostasis. Dysregulation of this process is associated with a wide variety of human diseases, including developmental and immunological disorders, neurodegenerative diseases and tumors. While the fundamental role of JNK pathway in cell death has been extensively studied, its down-stream regulators and the underlying mechanisms remain largely elusive. From a Drosophila genetic screen, we identified Snail (Sna), a Zinc-finger transcription factor, as a novel modulator of ectopic Egr-induced JNK-mediated cell death. In addition, sna is essential for the physiological function of JNK signaling in development. Our genetic epistasis data suggest that Sna acts downstream of JNK to promote cell death. Mechanistically, JNK signaling triggers dFoxO-dependent transcriptional activation of sna. Thus, our findings not only reveal a novel function and the underlying mechanism of Sna in modulating JNK-mediated cell death, but also provide a potential drug target and therapeutic strategies for JNK signaling-related diseases.
|
| 巻・号 |
10(12)
|
| ページ |
893
|
| 公開日 |
2019-11-26
|
| DOI |
10.1038/s41419-019-2135-7
|
| PII |
10.1038/s41419-019-2135-7
|
| PMID |
31772150
|
| PMC |
PMC6879600
|
| MeSH |
Animals
Apoptosis*
Drosophila Proteins / metabolism
Drosophila melanogaster / cytology*
Drosophila melanogaster / embryology
Drosophila melanogaster / genetics
Drosophila melanogaster / metabolism*
Eye / cytology
Eye / metabolism
Genes, Dominant
Genetic Testing
JNK Mitogen-Activated Protein Kinases / metabolism*
Larva / metabolism
MAP Kinase Signaling System
Phenotype
Snail Family Transcription Factors / genetics
Snail Family Transcription Factors / metabolism*
Transcription, Genetic
Wings, Animal / cytology
Wings, Animal / metabolism
|
| IF |
6.304
|
| 引用数 |
3
|
| リソース情報 |
| ショウジョウバエ |
4889R-4
3758R-1
3758R-5 |
