| RRC ID |
56250
|
| 著者 |
Zhou Y, Wang Y, Zhang X, Bhar S, Jones Lipinski RA, Han J, Feng L, Butcher RA.
|
| タイトル |
Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans.
|
| ジャーナル |
Elife
|
| Abstract |
Caenorhabditis elegans produces ascaroside pheromones to control its development and behavior. Even minor structural differences in the ascarosides have dramatic consequences for their biological activities. Here, we identify a mechanism that enables C. elegans to dynamically tailor the fatty-acid side chains of the indole-3-carbonyl (IC)-modified ascarosides it has produced. In response to starvation, C. elegans uses the peroxisomal acyl-CoA synthetase ACS-7 to activate the side chains of medium-chain IC-ascarosides for β-oxidation involving the acyl-CoA oxidases ACOX-1.1 and ACOX-3. This pathway rapidly converts a favorable ascaroside pheromone that induces aggregation to an unfavorable one that induces the stress-resistant dauer larval stage. Thus, the pathway allows the worm to respond to changing environmental conditions and alter its chemical message without having to synthesize new ascarosides de novo. We establish a new model for biosynthesis of the IC-ascarosides in which side-chain β-oxidation is critical for controlling the type of IC-ascarosides produced.
|
| 巻・号 |
7
|
| 公開日 |
2018-6-4
|
| DOI |
10.7554/eLife.33286
|
| PII |
33286
|
| PMID |
29863473
|
| PMC |
PMC5986272
|
| MeSH |
Acyl-CoA Oxidase / metabolism
Animals
Caenorhabditis elegans / growth & development
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / metabolism*
Coenzyme A Ligases / metabolism
Glycolipids / biosynthesis*
Glycolipids / chemistry
Larva / growth & development
Larva / metabolism
Models, Chemical
Molecular Structure
Oxidation-Reduction
Pheromones / biosynthesis*
Pheromones / chemistry
|
| IF |
7.551
|
| 引用数 |
7
|
| リソース情報 |
| 線虫 |
tm6415
tm4033 |
