| RRC ID |
56174
|
| 著者 |
Ishidate T, Ozturk AR, Durning DJ, Sharma R, Shen EZ, Chen H, Seth M, Shirayama M, Mello CC.
|
| タイトル |
ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals.
|
| ジャーナル |
Mol Cell
|
| Abstract |
Animal cells have a remarkable capacity to adopt durable and heritable gene expression programs or epigenetic states that define the physical properties and diversity of somatic cell types. The maintenance of epigenetic programs depends on poorly understood pathways that prevent gain or loss of inherited signals. In the germline, epigenetic factors are enriched in liquid-like perinuclear condensates called nuage. Here, we identify the deeply conserved helicase-domain protein, ZNFX-1, as an epigenetic regulator and component of nuage that interacts with Argonaute systems to balance epigenetic inheritance. Our findings suggest that ZNFX-1 promotes the 3' recruitment of machinery that propagates the small RNA epigenetic signal and thus counteracts a tendency for Argonaute targeting to shift 5' along the mRNA. These functional insights support the idea that recently identified subdomains of nuage, including ZNFX-1 granules or "Z-granules," may define spatial and temporal zones of molecular activity during epigenetic regulation.
|
| 巻・号 |
70(4)
|
| ページ |
639-649.e6
|
| 公開日 |
2018-5-17
|
| DOI |
10.1016/j.molcel.2018.04.009
|
| PII |
S1097-2765(18)30279-X
|
| PMID |
29775580
|
| PMC |
PMC5994929
|
| MeSH |
Animals
Argonaute Proteins / genetics
Argonaute Proteins / metabolism*
Caenorhabditis elegans / genetics*
Caenorhabditis elegans / metabolism
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism*
Cell Nucleus / genetics*
Epigenesis, Genetic*
Germ Cells / metabolism*
Organelles
RNA Helicases / genetics
RNA Helicases / metabolism*
RNA, Small Interfering / genetics*
RNA, Small Interfering / metabolism
RNA-Dependent RNA Polymerase / genetics
RNA-Dependent RNA Polymerase / metabolism
|
| IF |
14.548
|
| 引用数 |
17
|
| リソース情報 |
| 線虫 |
tm872
tm892 |
