| RRC ID |
55885
|
| 著者 |
Heestand B, Simon M, Frenk S, Titov D, Ahmed S.
|
| タイトル |
Transgenerational Sterility of Piwi Mutants Represents a Dynamic Form of Adult Reproductive Diapause.
|
| ジャーナル |
Cell Rep
|
| Abstract |
Environmental stress can induce adult reproductive diapause, a state of developmental arrest that temporarily suspends reproduction. Deficiency for C. elegans Piwi protein PRG-1 results in strains that reproduce for many generations but then become sterile. We found that sterile-generation prg-1/Piwi mutants typically displayed pronounced germ cell atrophy as L4 larvae matured into 1-day-old adults. Atrophied germlines spontaneously reproliferated across the first days of adulthood, and this was accompanied by fertility for day 2-4 adults. Sterile day 5 prg-1 mutant adults remained sterile indefinitely, but providing an alternative food source could restore their fertility. Our data imply that late-generation prg-1 mutants experience a dynamic form of adult reproductive diapause, promoted by stress response, cell death, and RNAi pathways, where delayed fertility and reproductive quiescence represent parallel adaptive developmental outcomes. This may occur in response to a form of "heritable stress" that is transmitted by gametes and epigenetic in nature.
|
| 巻・号 |
23(1)
|
| ページ |
156-171
|
| 公開日 |
2018-4-3
|
| DOI |
10.1016/j.celrep.2018.03.015
|
| PII |
S2211-1247(18)30344-9
|
| PMID |
29617657
|
| PMC |
PMC5918633
|
| MeSH |
Animals
Argonaute Proteins / genetics*
Caenorhabditis elegans
Caenorhabditis elegans Proteins / genetics*
Diapause*
Epigenesis, Genetic*
Fertility*
Gametogenesis
Germ Cells / cytology
Germ Cells / metabolism
Stress, Physiological
|
| IF |
7.815
|
| 引用数 |
9
|
| リソース情報 |
| 線虫 |
tm872
tm876 |
