| RRC ID |
55858
|
| 著者 |
Arey RN, Stein GM, Kaletsky R, Kauffman A, Murphy CT.
|
| タイトル |
Activation of Gαq Signaling Enhances Memory Consolidation and Slows Cognitive Decline.
|
| ジャーナル |
Neuron
|
| Abstract |
Perhaps the most devastating decline with age is the loss of memory. Therefore, identifying mechanisms to restore memory function with age is critical. Using C. elegans associative learning and memory assays, we identified a gain-of-function Gαq signaling pathway mutant that forms a long-term (cAMP response element binding protein [CREB]-dependent) memory following one conditioned stimulus-unconditioned stimulus (CS-US) pairing, which usually requires seven CS-US pairings. Increased CREB activity in AIM interneurons reduces the threshold for memory consolidation through transcription of a set of previously identified "long-term memory" genes. Enhanced Gαq signaling in the AWC sensory neuron is both necessary and sufficient for improved memory and increased AIM CREB activity, and activation of Gαq specifically in aged animals rescues the ability to form memory. Activation of Gαq in AWC sensory neurons non-cell autonomously induces consolidation after one CS-US pairing, enabling both cognitive function maintenance with age and restoration of memory function in animals with impaired memory performance without decreased longevity.
|
| 巻・号 |
98(3)
|
| ページ |
562-574.e5
|
| 公開日 |
2018-5-2
|
| DOI |
10.1016/j.neuron.2018.03.039
|
| PII |
S0896-6273(18)30245-9
|
| PMID |
29656871
|
| PMC |
PMC5934306
|
| MeSH |
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Cognitive Dysfunction / genetics
Cognitive Dysfunction / metabolism*
Cyclic AMP Response Element-Binding Protein / genetics
Cyclic AMP Response Element-Binding Protein / metabolism
GTP-Binding Protein alpha Subunits, Gq-G11 / genetics
GTP-Binding Protein alpha Subunits, Gq-G11 / metabolism*
Memory Consolidation / physiology*
Signal Transduction / physiology*
|
| IF |
14.403
|
| 引用数 |
5
|
| リソース情報 |
| 線虫 |
tm2411 |
