| RRC ID |
54396
|
| 著者 |
Boda A, Lőrincz P, Takáts S, Csizmadia T, Tóth S, Kovács AL, Juhász G.
|
| タイトル |
Drosophila Arl8 is a general positive regulator of lysosomal fusion events.
|
| ジャーナル |
Biochim Biophys Acta Mol Cell Res
|
| Abstract |
The small GTPase Arl8 is known to be involved in the periphery-directed motility of lysosomes. However, the overall importance of moving these vesicles is still poorly understood. Here we show that Drosophila Arl8 is required not only for the proper distribution of lysosomes, but also for autophagosome-lysosome fusion in starved fat cells, endosome-lysosome fusion in garland nephrocytes, and developmentally programmed secretory granule degradation (crinophagy) in salivary gland cells. Moreover, proper Arl8 localization to lysosomes depends on the shared subunits of the BLOC-1 and BORC complexes, which also promote autophagy and crinophagy. In conclusion, we demonstrate that Arl8 is responsible not only for positioning lysosomes but also acts as a general lysosomal fusion factor.
|
| 巻・号 |
1866(4)
|
| ページ |
533-544
|
| 公開日 |
2019-4-1
|
| DOI |
10.1016/j.bbamcr.2018.12.011
|
| PII |
S0167-4889(18)30256-8
|
| PMID |
30590083
|
| MeSH |
ADP-Ribosylation Factors / genetics
ADP-Ribosylation Factors / metabolism
ADP-Ribosylation Factors / physiology*
Animals
Autophagosomes / physiology
Drosophila Proteins / genetics
Drosophila Proteins / metabolism
Drosophila Proteins / physiology*
Drosophila melanogaster / physiology
Drosophila melanogaster / ultrastructure
Lysosomes / metabolism
Lysosomes / physiology*
Lysosomes / ultrastructure
Membrane Fusion
Protein Subunits / physiology
rab GTP-Binding Proteins / physiology
|
| IF |
4.739
|
| 引用数 |
4
|
| リソース情報 |
| ショウジョウバエ |
17180R-1
DGRC#140948
DGRC#141970
DGRC#141824 |
