| RRC ID |
53949
|
| 著者 |
Fassnacht C, Tocchini C, Kumari P, Gaidatzis D, Stadler MB, Ciosk R.
|
| タイトル |
The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans.
|
| ジャーナル |
PLoS Genet
|
| Abstract |
Endogenous RNAi (endoRNAi) is a conserved mechanism for fine-tuning gene expression. In the nematode Caenorhabditis elegans, several endoRNAi pathways are required for the successful development of reproductive cells. The CSR-1 endoRNAi pathway promotes germ cell development, primarily by facilitating the expression of germline genes. In this study, we report a novel function for the CSR-1 pathway in preventing premature activation of embryonic transcription in the developing oocytes, which is accompanied by a general Pol II activation. This CSR-1 function requires its RNase activity, suggesting that, by controlling the levels of maternal mRNAs, CSR-1-dependent endoRNAi contributes to an orderly reprogramming of transcription during the oocyte-to-embryo transition.
|
| 巻・号 |
14(3)
|
| ページ |
e1007252
|
| 公開日 |
2018-3-1
|
| DOI |
10.1371/journal.pgen.1007252
|
| PII |
PGENETICS-D-17-01790
|
| PMID |
29579041
|
| PMC |
PMC5886687
|
| MeSH |
Animals
Animals, Genetically Modified
Caenorhabditis elegans / embryology*
Caenorhabditis elegans / genetics*
Caenorhabditis elegans Proteins / genetics*
Caenorhabditis elegans Proteins / metabolism
Embryo, Nonmammalian
Female
Gene Expression Regulation, Developmental
Mutation
Oocytes / physiology*
RNA Interference*
RNA Polymerase II / genetics
RNA Polymerase II / metabolism
Transcription Factors / genetics
|
| IF |
5.175
|
| 引用数 |
2
|
| リソース情報 |
| 線虫 |
tm892
tm1217 |
