RRC ID 53539
著者 Denton D, Xu T, Dayan S, Nicolson S, Kumar S.
タイトル Dpp regulates autophagy-dependent midgut removal and signals to block ecdysone production.
ジャーナル Cell Death Differ
Abstract Animal development and homeostasis require the programmed removal of cells. Autophagy-dependent cell deletion is a unique form of cell death often involved in bulk degradation of tissues. In Drosophila the steroid hormone ecdysone controls developmental transitions and triggers the autophagy-dependent removal of the obsolete larval midgut. The production of ecdysone is exquisitely coordinated with signals from numerous organ systems to mediate the correct timing of such developmental programs. Here we report an unexpected role for the Drosophila bone morphogenetic protein/transforming growth factor β ligand, Decapentaplegic (Dpp), in the regulation of ecdysone-mediated midgut degradation. We show that blocking Dpp signaling induces premature autophagy, rapid cell death, and midgut degradation, whereas sustained Dpp signaling inhibits autophagy induction. Furthermore, Dpp signaling in the midgut prevents the expression of ecdysone responsive genes and impairs ecdysone production in the prothoracic gland. We propose that Dpp has dual roles: one within the midgut to prevent improper tissue degradation, and one in interorgan communication to coordinate ecdysone biosynthesis and developmental timing.
巻・号 26(4)
ページ 763-778
公開日 2019-3-1
DOI 10.1038/s41418-018-0154-z
PII 10.1038/s41418-018-0154-z
PMID 29959404
PMC PMC6460390
MeSH Animals Autophagic Cell Death* / genetics Autophagy / genetics* Autophagy / physiology Autophagy-Related Proteins / genetics Autophagy-Related Proteins / metabolism Drosophila / growth & development Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Ecdysone / metabolism* Gene Expression Regulation, Developmental Larva / cytology Larva / growth & development Larva / metabolism Lysosomes / genetics Lysosomes / metabolism Lysosomes / ultrastructure Metamorphosis, Biological / genetics* Signal Transduction / genetics Signal Transduction / physiology
IF 10.717
引用数 21
リソース情報
ショウジョウバエ 1765R-2 1765R-4