| RRC ID |
53538
|
| 著者 |
Yoshida A, Nakano S, Suzuki T, Ihara K, Higashiyama T, Mori I.
|
| タイトル |
A glial K(+) /Cl(-) cotransporter modifies temperature-evoked dynamics in Caenorhabditis elegans sensory neurons.
|
| ジャーナル |
Genes Brain Behav
|
| Abstract |
K(+) /Cl(-) cotransporters (KCCs) are known to be crucial in the control of neuronal electrochemical Cl(-) gradient. However, the role of these proteins in glial cells remains largely unexplored despite a number of studies showing expression of KCC proteins in glial cells of many species. Here, we show that the Caenorhabditis elegans K(+) /Cl(-) cotransporter KCC-3 is expressed in glial-like cells and regulates the thermosensory behavior through modifying temperature-evoked activity of a thermosensory neuron. Mutations in the kcc-3 gene were isolated from a genetic screen for mutants defective in thermotaxis. KCC-3 is expressed and functions in the amphid sheath glia that ensheathes the AFD neuron, a major thermosensory neuron known to be required for thermotaxis. A genetic analysis indicated that the regulation of the thermosensory behavior by KCC-3 is mediated through AFD, and we further show that KCC-3 in the amphid sheath glia regulates the dynamics of the AFD activity. Our results show a novel mechanism by which the glial KCC-3 protein non-cell autonomously modifies the stimulus-evoked activity of a sensory neuron and highlights the functional importance of glial KCC proteins in modulating the dynamics of a neural circuitry to control an animal behavior.
|
| 巻・号 |
15(4)
|
| ページ |
429-40
|
| 公開日 |
2016-4-1
|
| DOI |
10.1111/gbb.12260
|
| PMID |
26463820
|
| MeSH |
Animals
Animals, Genetically Modified
Behavior, Animal
Caenorhabditis elegans
Caenorhabditis elegans Proteins / genetics*
Caenorhabditis elegans Proteins / metabolism
Neuroglia / physiology*
Sensory Receptor Cells / metabolism
Symporters / genetics*
Symporters / metabolism
Temperature
|
| IF |
3.397
|
| 引用数 |
8
|
| リソース情報 |
| 線虫 |
tm3649 |
