RRC ID 53511
著者 Barrett A, Hermann GJ.
タイトル A Caenorhabditis elegans Homologue of LYST Functions in Endosome and Lysosome-Related Organelle Biogenesis.
ジャーナル Traffic
Abstract LYST-1 is a Caenorhabditis elegans BEACH domain containing protein (BDCP) homologous to LYST and NBEAL2, BDCPs controlling organelle biogenesis that are implicated in human disease. Unlike the three other BDCPs encoded by C. elegans, mutations in lyst-1 lead to smaller lysosome-related organelles (LROs), smaller lysosomes, increased numbers of LROs and decreased numbers of early endosomes. lyst-1(-) mutations do not obviously disrupt protein trafficking to lysosomes or LROs, however, the formation of gut granules is diminished.
巻・号 17(5)
ページ 515-35
公開日 2016-5-1
DOI 10.1111/tra.12381
PMID 26822177
MeSH Animals Caenorhabditis elegans / metabolism* Endosomes / metabolism* Lysosomes / metabolism* Vesicular Transport Proteins / genetics Vesicular Transport Proteins / metabolism*
IF 4.045
引用数 6
リソース情報
線虫 tm920 tm592