RRC ID 53413
著者 Minkina O, Hunter CP.
タイトル Stable Heritable Germline Silencing Directs Somatic Silencing at an Endogenous Locus.
ジャーナル Mol Cell
Abstract The importance of transgenerationally inherited epigenetic states to organismal fitness remains unknown as well-documented examples are often not amenable to mechanistic analysis or rely on artificial reporter loci. Here we describe an induced silenced state at an endogenous locus that persists, at 100% transmission without selection, for up to 13 generations. This unusually persistent silencing enables a detailed molecular genetic analysis of an inherited epigenetic state. We find that silencing is dependent on germline nuclear RNAi factors and post-transcriptional mechanisms. Consistent with these later observations, inheritance does not require the silenced locus, and we provide genetic evidence that small RNAs embody the inherited silencing signal. Notably, heritable germline silencing directs somatic epigenetic silencing. Somatic silencing does not require somatic nuclear RNAi but instead requires both maternal germline nuclear RNAi and chromatin-modifying activity. Coupling inherited germline silencing to somatic silencing may enable selection for physiologically important traits.
巻・号 65(4)
ページ 659-670.e5
公開日 2017-2-16
DOI 10.1016/j.molcel.2017.01.034
PII S1097-2765(17)30092-8
PMID 28212751
PMC PMC5389115
MeSH 5' Untranslated Regions Animals Animals, Genetically Modified Argonaute Proteins / genetics Argonaute Proteins / metabolism Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Chromatin / genetics Chromatin / metabolism Chromatin Assembly and Disassembly Gene Silencing* Genetic Loci* Genotype Heredity Inheritance Patterns* Membrane Proteins / genetics* Membrane Proteins / metabolism Nuclear Proteins / genetics Nuclear Proteins / metabolism Phenotype Promoter Regions, Genetic RNA Interference* RNA Precursors / genetics RNA Precursors / metabolism RNA, Messenger / genetics RNA, Messenger / metabolism RNA, Small Interfering / genetics* RNA, Small Interfering / metabolism
IF 15.584
引用数 18
リソース情報
線虫 tm1200