RRC ID 53329
著者 Chen D, Taylor KP, Hall Q, Kaplan JM.
タイトル The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion.
ジャーナル Genetics
Abstract During larval molts, Caenorhabditis elegans exhibits a sleep-like state (termed lethargus) that is characterized by the absence of feeding and profound locomotion quiescence. The rhythmic pattern of locomotion quiescence and arousal linked to the molting cycle is mediated by reciprocal changes in sensory responsiveness, whereby arousal is associated with increased responsiveness. Sensory neurons arouse locomotion via release of a neuropeptide (PDF-1) and glutamate. Here we identify a second arousing neuropeptide (FLP-2). We show that FLP-2 acts via an orexin-like receptor (FRPR-18), and that FLP-2 and PDF-1 secretion are regulated by reciprocal positive feedback. These results suggest that the aroused behavioral state is stabilized by positive feedback between two neuropeptides.
巻・号 204(3)
ページ 1151-1159
公開日 2016-11-1
DOI 10.1534/genetics.116.192898
PII genetics.116.192898
PMID 27585848
PMC PMC5105848
MeSH Animals Arousal* Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Feedback, Physiological Glutamic Acid / metabolism Locomotion* Neuropeptides / genetics* Neuropeptides / metabolism Orexin Receptors / genetics Orexin Receptors / metabolism Sensory Receptor Cells / metabolism Sensory Receptor Cells / physiology
IF 4.015
引用数 27
リソース情報
線虫 tm1996