論文 - 詳細
| RRC ID | 53277 |
|---|---|
| 著者 | Lucanic M, Garrett T, Yu I, Calahorro F, Asadi Shahmirzadi A, Miller A, Gill MS, Hughes RE, Holden-Dye L, Lithgow GJ. |
| タイトル | Chemical activation of a food deprivation signal extends lifespan. |
| ジャーナル | Aging Cell |
| Abstract |
Model organisms subject to dietary restriction (DR) generally live longer. Accompanying this lifespan extension are improvements in overall health, based on multiple metrics. This indicates that pharmacological treatments that mimic the effects of DR could improve health in humans. To find new chemical structures that extend lifespan, we screened 30 000 synthetic, diverse drug-like chemicals in Caenorhabditis elegans and identified several structurally related compounds that acted through DR mechanisms. The most potent of these NP1 impinges upon a food perception pathway by promoting glutamate signaling in the pharynx. This results in the overriding of a GPCR pathway involved in the perception of food and which normally acts to decrease glutamate signals. Our results describe the activation of a dietary restriction response through the pharmacological masking of a novel sensory pathway that signals the presence of food. This suggests that primary sensory pathways may represent novel targets for human pharmacology. |
| 巻・号 | 15(5) |
| ページ | 832-41 |
| 公開日 | 2016-10-1 |
| DOI | 10.1111/acel.12492 |
| PMID | 27220516 |
| PMC | PMC5013014 |
| MeSH | Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Caloric Restriction Chloride Channels / metabolism Feeding Behavior / drug effects Food Deprivation / physiology* Glutamates / metabolism Longevity / drug effects Longevity / physiology* Models, Biological Muscle Contraction / drug effects Mutation / genetics Pharynx / drug effects Pharynx / physiology Receptors, Muscarinic / genetics Receptors, Muscarinic / metabolism Signal Transduction* / drug effects Small Molecule Libraries / analysis Small Molecule Libraries / chemistry Small Molecule Libraries / pharmacology |
| IF | 7.238 |
| 引用数 | 8 |
| リソース情報 | |
| 線虫 | tm1325 |