RRC ID 51531
著者 Sato-Carlton A, Nakamura-Tabuchi C, Chartrand SK, Uchino T, Carlton PM.
タイトル Phosphorylation of the synaptonemal complex protein SYP-1 promotes meiotic chromosome segregation.
ジャーナル J Cell Biol
Abstract Chromosomes that have undergone crossing over in meiotic prophase must maintain sister chromatid cohesion somewhere along their length between the first and second meiotic divisions. Although many eukaryotes use the centromere as a site to maintain cohesion, the holocentric organism Caenorhabditis elegans instead creates two chromosome domains of unequal length termed the short arm and long arm, which become the first and second site of cohesion loss at meiosis I and II. The mechanisms that confer distinct functions to the short and long arm domains remain poorly understood. Here, we show that phosphorylation of the synaptonemal complex protein SYP-1 is required to create these domains. Once crossover sites are designated, phosphorylated SYP-1 and PLK-2 become cooperatively confined to short arms and guide phosphorylated histone H3 and the chromosomal passenger complex to the site of meiosis I cohesion loss. Our results show that PLK-2 and phosphorylated SYP-1 ensure creation of the short arm subdomain, promoting disjunction of chromosomes in meiosis I.
巻・号 217(2)
ページ 555-570
公開日 2018-2-5
DOI 10.1083/jcb.201707161
PII jcb.201707161
PMID 29222184
PMC PMC5800814
MeSH Animals Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism* Chromosome Segregation* Meiosis* Nuclear Proteins / metabolism* Phosphorylation Synaptonemal Complex / metabolism*
IF 8.811
引用数 6
リソース情報
線虫 tm301 tm574