| RRC ID |
51526
|
| 著者 |
Martin E, Bonnamour G, Jenna S.
|
| タイトル |
AMPK and autophagy control embryonic elongation as part of a RhoA-like morphogenic program in nematode.
|
| ジャーナル |
Small GTPases
|
| Abstract |
Autophagy is the process where cytosolic components are digested by the cell. This process is required for cell survival in stressful conditions. It was also shown to control cell division and more recently, cell morphology and migration. We characterized signalling pathways enabling embryonic epidermal cells of the nematode Caenorhabditis elegans to elongate along their antero-posterior axis. Previous studies revealed that epidermal cells can adopt either a RhoA-like or a Rac1-like morphogenic program. We show here that the AMP-activated protein kinase (AMPK) and genes controlling autophagy are required for proper elongation of epidermal cells following the RhoA-like program and are dispensable for other cells. This suggests that AMPK-autophagy is used by the embryo to fuel the most energy-demanding morphogenic processes promoting early elongation.
|
| 巻・号 |
11(3)
|
| ページ |
186-193
|
| 公開日 |
2020-5-1
|
| DOI |
10.1080/21541248.2017.1372868
|
| PMID |
29172954
|
| PMC |
PMC7549676
|
| MeSH |
AMP-Activated Protein Kinases / genetics
AMP-Activated Protein Kinases / metabolism*
Animals
Autophagy* / genetics
Caenorhabditis elegans / metabolism*
Epidermal Cells / metabolism
Signal Transduction / genetics
|
| リソース情報 |
| 線虫 |
tm1944 |
