RRC ID 51501
著者 Palominos MF, Verdugo L, Gabaldon C, Pollak B, Ortíz-Severín J, Varas MA, Chávez FP, Calixto A.
タイトル Transgenerational Diapause as an Avoidance Strategy against Bacterial Pathogens in Caenorhabditis elegans.
ジャーナル mBio
Abstract The dynamic response of organisms exposed to environmental pathogens determines their survival or demise, and the outcome of this interaction depends on the host's susceptibility and pathogen-dependent virulence factors. The transmission of acquired information about the nature of a pathogen to progeny may ensure effective defensive strategies for the progeny's survival in adverse environments. Environmental RNA interference (RNAi) is a systemic and heritable mechanism and has recently been linked to antibacterial and antifungal defenses in both plants and animals. Here, we report that the second generation of Caenorhabditis elegans living on pathogenic bacteria can avoid bacterial infection by entering diapause in an RNAi pathway-dependent mechanism. Furthermore, we demonstrate that the information encoding this survival strategy is transgenerationally transmitted to the progeny via the maternal germ line.IMPORTANCE Bacteria vastly influence physiology and behavior, and yet, the specific mechanisms by which they cause behavioral changes in hosts are not known. We use C. elegans as a host and the bacteria they eat to understand how microbes trigger a behavioral change that helps animals to survive. We found that animals faced with an infection for two generations could enter a hibernationlike state, arresting development by forming dauer larvae. Dauers have closed mouths and effectively avoid infection. Animals accumulate information that is transgenerationally transmitted to the next generations to form dauers. This work gives insight on how bacteria communicate in noncanonical ways with their hosts, resulting in long-lasting effects providing survival strategies to the community.
巻・号 8(5)
公開日 2017-10-10
DOI 10.1128/mBio.01234-17
PII mBio.01234-17
PMID 29018118
PMC PMC5635688
MeSH Animals Bacteria / pathogenicity* Caenorhabditis elegans / microbiology* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Diapause* Host-Pathogen Interactions / genetics Host-Pathogen Interactions / physiology Larva / physiology RNA Interference* RNA, Small Interfering / genetics Signal Transduction
IF 6.784
引用数 8
リソース情報
線虫 tm1019 tm110 tm1113 tm1116 tm1127 tm1144 tm1186 tm1195 tm1200 tm1414 tm1860 tm2686 tm4328 tm887 tm894 tm914