RRC ID 51486
著者 Kim B, Emmons SW.
タイトル Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans.
ジャーナル Elife
Abstract Nervous system function relies on precise synaptic connections. A number of widely-conserved cell adhesion proteins are implicated in cell recognition between synaptic partners, but how these proteins act as a group to specify a complex neural network is poorly understood. Taking advantage of known connectivity in C. elegans, we identified and studied cell adhesion genes expressed in three interacting neurons in the mating circuits of the adult male. Two interacting pairs of cell surface proteins independently promote fasciculation between sensory neuron HOA and its postsynaptic target interneuron AVG: BAM-2/neurexin-related in HOA binds to CASY-1/calsyntenin in AVG; SAX-7/L1CAM in sensory neuron PHC binds to RIG-6/contactin in AVG. A third, basal pathway results in considerable HOA-AVG fasciculation and synapse formation in the absence of the other two. The features of this multiplexed mechanism help to explain how complex connectivity is encoded and robustly established during nervous system development.
巻・号 6
公開日 2017-9-13
DOI 10.7554/eLife.29257
PII 29257
PMID 28901288
PMC PMC5619950
MeSH Animals Caenorhabditis elegans / physiology* Cell Adhesion* Connectome Gene Expression Profiling Male Nerve Net / physiology* Neural Cell Adhesion Molecules / genetics Neural Cell Adhesion Molecules / metabolism* Neurons / physiology*
IF 7.08
引用数 12
リソース情報
線虫 tm718