| RRC ID |
51458
|
| 著者 |
Rojo Romanos T, Pladevall-Morera D, Langebeck-Jensen K, Hansen S, Ng L, Pocock R.
|
| タイトル |
LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans.
|
| ジャーナル |
Sci Rep
|
| Abstract |
Development of complex nervous systems requires precisely controlled neurogenesis. The generation and specification of neurons occur through the transcriptional and post-transcriptional control of complex regulatory networks. In vertebrates and invertebrates, the proneural basic-helix-loop-helix (bHLH) family of transcription factors has multiple functions in neurogenesis. Here, we identified the LIN-32/Atonal bHLH transcription factor as a key regulator of URXL/R oxygen-sensing neuron development in Caenorhabditis elegans. When LIN-32/Atonal expression is lost, the expression of URX specification and terminal differentiation genes is abrogated. As such, lin-32 mutant animals are unable to respond to increases in environmental oxygen. The URX neurons are generated from a branch of the cell lineage that also produces the CEPDL/R and URADL/R neurons. We found development of these neurons is also defective, suggesting that LIN-32/Atonal regulates neuronal development of the entire lineage. Finally, our results show that aspects of URX neuronal fate are partially restored in lin-32 mutant animals when the apoptosis pathway is inhibited. This suggests that, as in other organisms, LIN-32/Atonal regulates neuronal apoptosis.
|
| 巻・号 |
7(1)
|
| ページ |
7294
|
| 公開日 |
2017-8-4
|
| DOI |
10.1038/s41598-017-07876-4
|
| PII |
10.1038/s41598-017-07876-4
|
| PMID |
28779171
|
| PMC |
PMC5544745
|
| MeSH |
Animals
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism*
Gene Expression
Genes, Reporter
Mutation
Neurogenesis*
Neurons / metabolism*
Oxygen / metabolism*
Transcription Factors / genetics
Transcription Factors / metabolism*
|
| IF |
3.998
|
| 引用数 |
1
|
| リソース情報 |
| 線虫 |
tm1446
tm1768 |
