RRC ID 51412
著者 Shen Q, Shi H, Tian C, Ghai V, Liu J.
タイトル The C. elegans Spalt-like protein SEM-4 functions through the SoxC transcription factor SEM-2 to promote a proliferative blast cell fate in the postembryonic mesoderm.
ジャーナル Dev Biol
Abstract Proper development of a multicellular organism relies on well-coordinated regulation of cell fate specification, cell proliferation and cell differentiation. The C. elegans postembryonic mesoderm provides a useful system for uncovering factors involved in these processes and for further dissecting their regulatory relationships. The single Spalt-like zinc finger containing protein SEM-4/SALL is known to be involved in specifying the proliferative sex myoblast (SM) fate. We have found that SEM-4/SALL is sufficient to promote the SM fate and that it does so in a cell autonomous manner. We further showed that SEM-4/SALL acts through the SoxC transcription factor SEM-2 to promote the SM fate. SEM-2 is known to promote the SM fate by inhibiting the expression of two BWM-specifying transcription factors. In light of recent findings in mammals showing that Sall4, one of the mammalian homologs of SEM-4, contributes to pluripotency regulation by inhibiting differentiation, our work suggests that the function of SEM-4/SALL proteins in regulating pluripotency versus differentiation appears to be evolutionarily conserved.
巻・号 429(1)
ページ 335-342
公開日 2017-9-1
DOI 10.1016/j.ydbio.2017.06.011
PII S0012-1606(17)30310-X
PMID 28614700
PMC PMC5554739
MeSH Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism* Cell Differentiation Cell Lineage* Cell Proliferation DNA-Binding Proteins / metabolism* Embryo, Nonmammalian / cytology* Gene Expression Regulation, Developmental Mesoderm / cytology* Models, Biological Mutation / genetics Regulatory Sequences, Nucleic Acid / genetics SOXC Transcription Factors / metabolism*
IF 2.896
引用数 0
リソース情報
線虫 tm547