RRC ID 51350
著者 Cai H, Rasulova M, Vandemeulebroucke L, Meagher L, Vlaeminck C, Dhondt I, Braeckman BP.
タイトル Life-Span Extension by Axenic Dietary Restriction Is Independent of the Mitochondrial Unfolded Protein Response and Mitohormesis in Caenorhabditis elegans.
ジャーナル J Gerontol A Biol Sci Med Sci
Abstract In Caenorhabditis elegans, a broad range of dietary restriction regimens extend life span to different degrees by separate or partially overlapping molecular pathways. One of these regimens, axenic dietary restriction, doubles the worm's life span but currently, almost nothing is known about the underlying molecular mechanism. Previous studies suggest that mitochondrial stress responses such as the mitochondrial unfolded protein response (UPRmt) or mitohormesis may play a vital role in axenic dietary restriction-induced longevity. Here, we provide solid evidence that axenic dietary restriction treatment specifically induces an UPRmt response in C elegans but this induction is not required for axenic dietary restriction-mediated longevity. We also show that reactive oxygen species-mediated mitohormesis is not involved in this phenotype. Hence, changes in mitochondrial physiology and induction of a mitochondrial stress response are not necessarily causal to large increases in life span.
巻・号 72(10)
ページ 1311-1318
公開日 2017-10-1
DOI 10.1093/gerona/glx013
PII 3074367
PMID 28329170
PMC PMC5861982
MeSH Age Factors Animals Caenorhabditis elegans / metabolism* Caloric Restriction* Life Expectancy* Mitochondria / metabolism* Oxidative Stress Phenotype Reactive Oxygen Species / metabolism Unfolded Protein Response
IF 4.902
引用数 4
リソース情報
線虫 tm4525