論文 - 詳細
| RRC ID | 50284 |
|---|---|
| 著者 | Ahn HM, Lee KS, Lee DS, Yu K. |
| タイトル | JNK/FOXO mediated PeroxiredoxinV expression regulates redox homeostasis during Drosophila melanogaster gut infection. |
| ジャーナル | Dev Comp Immunol |
| Abstract |
Innate immunity plays an important role in combating microbial infection in animals. During bacterial infection in Drosophila melanogaster gut, Dual oxidase (Duox) generates reactive oxygen species (ROS) to fight against the infected microbes. Concurrently, antioxidant systems eliminate residual ROS and protect the hosts. Here we found that Drosophila melanogaster Peroxiredoxin V (dPrxV) is an immune-related antioxidant enzyme which maintains intestinal redox homeostasis. dPrxV was highly expressed in gut and induced by the oral infection of Erwinia carotovora carotovora. dPrxV expression was increased by the gut-specific Duox overexpression but decreased by Duox inhibition. Moreover, dPrxV expression was mediated by the JNK/FOXO signaling and dPrxV mutant reduced survival after gut infection. These results suggest that JNK/FOXO mediated dPrxV expression plays a critical role in Drosophila melanogaster gut during bacterial infection in protecting the host gut epithelial cells from oxidative damage. |
| 巻・号 | 38(3) |
| ページ | 466-73 |
| 公開日 | 2012-11-1 |
| DOI | 10.1016/j.dci.2012.07.002 |
| PII | S0145-305X(12)00158-9 |
| PMID | 22858408 |
| MeSH | Amino Acid Sequence Animals Antioxidants / metabolism Drosophila Proteins / immunology Drosophila Proteins / metabolism Drosophila melanogaster / enzymology* Drosophila melanogaster / immunology Drosophila melanogaster / metabolism Drosophila melanogaster / microbiology* Forkhead Transcription Factors / metabolism Gastrointestinal Tract / immunology Gastrointestinal Tract / metabolism* Gastrointestinal Tract / microbiology Homeostasis JNK Mitogen-Activated Protein Kinases / metabolism Molecular Sequence Data NADPH Oxidases / metabolism Oxidative Stress / immunology Pectobacterium carotovorum / immunology Pectobacterium carotovorum / pathogenicity Peroxiredoxins / chemistry Peroxiredoxins / metabolism* Reactive Oxygen Species Sequence Alignment Signal Transduction / immunology |
| IF | 3.192 |
| 引用数 | 21 |
| リソース情報 | |
| ショウジョウバエ | 5680R-1 5680R-2 |