RRC ID 47989
著者 Schartl M, Walter RB.
タイトル Xiphophorus and Medaka Cancer Models.
ジャーナル Adv Exp Med Biol
Abstract Besides recently developed zebrafish cancer models, other fish species have been employed for many years as cancer models in laboratory studies. Two models, namely in Xiphophorus and medaka have proven useful in providing important clues to cancer etiology. Medaka is a complementary model to zebrafish in many areas of research since it offers similar resources and experimental tools. Xiphophorus provides the advantages of a natural ("evolutionary mutant") model with established genetics. Xiphophorus hybrids can develop spontaneous and radiation or carcinogen induced cancers. This chapter describes the tumor models in both species, which mainly focus on melanoma, and summarizes the main findings and future research directions.
巻・号 916
ページ 531-52
公開日 2016-1-1
DOI 10.1007/978-3-319-30654-4_23
PMID 27165369
MeSH Animals Animals, Genetically Modified Carcinogens / toxicity Cyprinodontiformes Disease Models, Animal* Genes, Tumor Suppressor Neoplasms / chemically induced Neoplasms / genetics Neoplasms / pathology* Oncogenes Zebrafish
IF 2.45
引用数 10
リソース情報
メダカ database IB180 HO4C HB32C