論文 - 詳細
| RRC ID | 46745 |
|---|---|
| 著者 | Youds JL, Mets DG, McIlwraith MJ, Martin JS, Ward JD, ONeil NJ, Rose AM, West SC, Meyer BJ, Boulton SJ. |
| タイトル | RTEL-1 enforces meiotic crossover interference and homeostasis. |
| ジャーナル | Science |
| Abstract |
Meiotic crossovers (COs) are tightly regulated to ensure that COs on the same chromosome are distributed far apart (crossover interference, COI) and that at least one CO is formed per homolog pair (CO homeostasis). CO formation is controlled in part during meiotic double-strand break (DSB) creation in Caenorhabditis elegans, but a second level of control must also exist because meiotic DSBs outnumber COs. We show that the antirecombinase RTEL-1 is required to prevent excess meiotic COs, probably by promoting meiotic synthesis-dependent strand annealing. Two distinct classes of meiotic COs are increased in rtel-1 mutants, and COI and homeostasis are compromised. We propose that RTEL-1 implements the second level of CO control by promoting noncrossovers. |
| 巻・号 | 327(5970) |
| ページ | 1254-8 |
| 公開日 | 2010-3-5 |
| DOI | 10.1126/science.1183112 |
| PII | 327/5970/1254 |
| PMID | 20203049 |
| PMC | PMC4770885 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Chromatids / genetics Chromosomal Proteins, Non-Histone / genetics Chromosomal Proteins, Non-Histone / metabolism Crossing Over, Genetic* DNA Breaks, Double-Stranded DNA Helicases / genetics DNA Helicases / metabolism* DNA Repair DNA, Helminth / genetics DNA, Helminth / metabolism Homeostasis Meiosis* Mutation Polymorphism, Single Nucleotide X Chromosome / genetics |
| IF | 41.846 |
| 引用数 | 115 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm1866 |