RRC ID 46600
著者 Hallem EA, Spencer WC, McWhirter RD, Zeller G, Henz SR, Rätsch G, Miller DM 3rd, Horvitz HR, Sternberg PW, Ringstad N.
タイトル Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.
ジャーナル Proc Natl Acad Sci U S A
Abstract CO(2) is both a critical regulator of animal physiology and an important sensory cue for many animals for host detection, food location, and mate finding. The free-living soil nematode Caenorhabditis elegans shows CO(2) avoidance behavior, which requires a pair of ciliated sensory neurons, the BAG neurons. Using in vivo calcium imaging, we show that CO(2) specifically activates the BAG neurons and that the CO(2)-sensing function of BAG neurons requires TAX-2/TAX-4 cyclic nucleotide-gated ion channels and the receptor-type guanylate cyclase GCY-9. Our results delineate a molecular pathway for CO(2) sensing and suggest that activation of a receptor-type guanylate cyclase is an evolutionarily conserved mechanism by which animals detect environmental CO(2).
巻・号 108(1)
ページ 254-9
公開日 2011-1-4
DOI 10.1073/pnas.1017354108
PII 1017354108
PMID 21173231
PMC PMC3017194
MeSH Animals Base Sequence Biological Evolution Caenorhabditis elegans / enzymology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Carbon Dioxide / metabolism* Carbon Dioxide / toxicity Chemotaxis / drug effects Chemotaxis / physiology* Cluster Analysis DNA Primers / genetics Gene Components Guanylate Cyclase / metabolism* Ion Channels / metabolism* Microscopy, Confocal Molecular Sequence Data Neurons / metabolism* Phylogeny Receptors, Guanylate Cyclase-Coupled / metabolism* Sequence Analysis, DNA Smell / genetics Smell / physiology* Transgenes / genetics
IF 9.412
引用数 67
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 tm2816 tm2669 tm16530 tm1449 tm901 tm4516 tm2364 tm4300 tm2411