論文 - 詳細
RRC ID | 46600 |
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著者 | Hallem EA, Spencer WC, McWhirter RD, Zeller G, Henz SR, Rätsch G, Miller DM 3rd, Horvitz HR, Sternberg PW, Ringstad N. |
タイトル | Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans. |
ジャーナル | Proc Natl Acad Sci U S A |
Abstract |
CO(2) is both a critical regulator of animal physiology and an important sensory cue for many animals for host detection, food location, and mate finding. The free-living soil nematode Caenorhabditis elegans shows CO(2) avoidance behavior, which requires a pair of ciliated sensory neurons, the BAG neurons. Using in vivo calcium imaging, we show that CO(2) specifically activates the BAG neurons and that the CO(2)-sensing function of BAG neurons requires TAX-2/TAX-4 cyclic nucleotide-gated ion channels and the receptor-type guanylate cyclase GCY-9. Our results delineate a molecular pathway for CO(2) sensing and suggest that activation of a receptor-type guanylate cyclase is an evolutionarily conserved mechanism by which animals detect environmental CO(2). |
巻・号 | 108(1) |
ページ | 254-9 |
公開日 | 2011-1-4 |
DOI | 10.1073/pnas.1017354108 |
PII | 1017354108 |
PMID | 21173231 |
PMC | PMC3017194 |
MeSH | Animals Base Sequence Biological Evolution Caenorhabditis elegans / enzymology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Carbon Dioxide / metabolism* Carbon Dioxide / toxicity Chemotaxis / drug effects Chemotaxis / physiology* Cluster Analysis DNA Primers / genetics Gene Components Guanylate Cyclase / metabolism* Ion Channels / metabolism* Microscopy, Confocal Molecular Sequence Data Neurons / metabolism* Phylogeny Receptors, Guanylate Cyclase-Coupled / metabolism* Sequence Analysis, DNA Smell / genetics Smell / physiology* Transgenes / genetics |
IF | 9.412 |
引用数 | 67 |
WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
リソース情報 | |
線虫 | tm2816 tm2669 tm16530 tm1449 tm901 tm4516 tm2364 tm4300 tm2411 |